Phenoxybenzamine (HCl)

Phenoxybenzamine (HCl) is irreversible a-adrenergic blocking agent, with a non-selective, covalent biniding with both a1 post-synaptic and a2 presynaptic receptors.Chemically related to nitrogen mustard. it has a long duration of action. Phenoxybenzamine (HCl) is used to control hypertension and sweating in pheochromocytoma, to treat Raynaud`s phenomenon, to treat micturation disorders resulting from neurogenic bladder dysfunction.

Brands
Adult Dose
Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: 24 hourly
Route: IV Inf
Instructions: For atleast 2 hrs., As Required
Neonatal
Paedriatic
Dose: 0.5 to 1 mg/kg
Single Dose: 0.75 (0.75)
Frequency: 12 hourly
Route: Oral
Instructions: For Paeds of All Ages
Characteristics
. It is of Synthetic origin and belongs to Haloalkylamines. It belongs to Alpha adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Phenoxybenzamine (HCl) is 340.30.
Contraindications
Phenoxybenzamine (HCl) is contraindicated in conditions like Orthostatic hypotension,Fluid depletion.
Effects
The severe or irreversible adverse effects of Phenoxybenzamine (HCl), which give rise to further complications include Postoperative hypotension.Phenoxybenzamine (HCl) produces potentially life-threatening effects which include Postural hypotension. which are responsible for the discontinuation of Phenoxybenzamine (HCl) therapy.The symptomatic adverse reactions produced by Phenoxybenzamine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Lethargy, Sedation, Nasal stiffiness, Nausea and vomiting, Miosis, Ejaculatory failure.
Indications
'Phenoxybenzamine (HCl) is primarily indicated in conditions like Adjunct in hypertensive episodes in pheochromocytoma, Hypertension, Hypertensive episodes in phaeochromocytoma, Phaeochromocytoma, and can also be given in adjunctive therapy as an alternative drug of choice in Raynaud''s phenomenon, Urinary obstruction.'
Interactions
Phenoxybenzamine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAdrenalineClonidine (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
None well documented
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Phenoxybenzamine should be used with caution in patients with marked cerebral or coronary arteriosclerosis or renal (kidney) damage.
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