Ketanserin (Tartrate)

Chemically Ketanserin (Tartrate) is (+)-3-[2-[4-fluorobenzoyl)-1-piperidinyl]-2, 4 [1H, 3H]-quinazoline-dione. Ketanserin (Tartrate) is prepared by chemical synthesis and the dextrorotatary stereoisomer is used clinically. Ketanserin (Tartrate) is a serotonin antagonist with a high affinity for peripheral serotonin-2 (5-HT-2) receptors and thus inhibits serotonin-induced vasoconstriction, bronchoconstriction and platelet aggregation.it has also some a-1 antagonist and histamine H-1antagonist properties, but the clinical significance of these is controversial. Ketanserin is used in the management of hypertension and has also been tried in a variety of other conditions.

Brands
Adult Dose
Dose: 0.142 mg/kg
Single Dose: 0.14 (0.142)
Frequency: As recommended.
Route: IM
Instructions: Every 15-30 minutes, As Required
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to 2.4(1h,3h) Quinazolivedione. It belongs to 5HT-2 + alpha adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antihypertensive Agents pharmacological group.The Molecular Weight of Ketanserin (Tartrate) is 545.52. Its pKa is 7.5.
Contraindications
Ketanserin (Tartrate) is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Ketanserin (Tartrate), which give rise to further complications include Ventricular tachycardia.Ketanserin (Tartrate) produces potentially life-threatening effects which include Ventricular arrhythmias. which are responsible for the discontinuation of Ketanserin (Tartrate) therapy.The signs and symptoms that are produced after the acute overdosage of Ketanserin (Tartrate) include Drowsiness, Visual distrubances, Syncope, Sleepiness.The symptomatic adverse reactions produced by Ketanserin (Tartrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Fatigue, Dry mouth, Sedation, Light headedness, Lack of concentration, GI disturbance, Dry mouth, dizziness.
Indications
Ketanserin (Tartrate) is primarily indicated in conditions like Acute hypertensive episodes, Essential hypertension, and can also be given in adjunctive therapy as an alternative drug of choice in Bronchospasm, Vasodilator.
Interactions
No data regarding the interactions of Ketanserin (Tartrate) was found.
Interfrence
Risks
Drug should not be given to patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness. Ketanserin should be used with caution in patients receiving antiarrhythmics or those with 2nd or 3rd degree A.V. block. Caution should be taken to avoid hypokalaemia in patients taken ketanserin with diuretics.
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