Xylometazoline (HCl)

Chemically Xylometazoline (HCl) is 2-(4-tert-butyl-2, 6-dimethylbenzyl)-2-imidazoline. Xylometazoline (HCl) is a direct acting alpha-adrenoceptor agonist, used as vasoconstrictor for nasal decongestion. It promotes nasal drainage and relieves nasal stuffiness. Xylometazoline (HCl) is used to relieve symptoms associated with a cold, hay fever, allergies, sinus infections and other related conditions.

Brands
LYZO NASAVIN XYNOSINE OXYCROM XOLISAN RHEZOLE XLOMET XLOMET XYLONAS XYNOSINE C.F XYLOMETAZOLINE XYLOMED
Adult Dose
Dose: 0.10%
Single Dose: 0.1 (0.1)
Frequency: 8 hourly
Route: Intra Nasal
Instructions: 2-3 drops in each nostril.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 0.1 to 0.15 mg
Single Dose: 0.12 (0.125)
Frequency: 8 hourly
Route: Opthalmic
Instructions: -
Characteristics
Xylometazoline is the derivative of Xylometazoline (HCl). It is of Synthetic origin and belongs to Imidazole. It belongs to Alpha-2 adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Nasal Decongestants and Opthalmic Agent, Vasoconstrictor pharmacological group.The Molecular Weight of Xylometazoline (HCl) is 280.80. It is weakly acidic drug, 4.68% solution of the drug is isotonic.
Contraindications
Xylometazoline (HCl) is contraindicated in conditions like Diabetes mellitus,Hypertension,Narrow-angle glaucoma,Vasomotor rhinitis,Atrophic rhinitis.
Effects
The severe or irreversible adverse effects of Xylometazoline (HCl), which give rise to further complications include Rhinitis medicamentosa.The symptomatic adverse reactions produced by Xylometazoline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Stinging on application, Dryness of eye, Dryness of nose.
Indications
Xylometazoline (HCl) is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis, Eye inflammation, Nasal congestion, Ocular congestion, Otitis media, Sinusitis.
Interactions
No data regarding the interactions of Xylometazoline (HCl) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Neonates, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Nasal Spray Store Below 40°C. Do not Freeze.
Warnings
Use topical decongestant (xylometazoline) only in acute conditions, not longer than 3 to 5 days. It should be used sparingly in all patients, especially in infants, children and in cardiac patients.
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