Beclomethasone (Dipropionate)

Beclomethasone is a synthetic halogenated inhaled glucocorticoid. Beclomethasone (Dipropionate) is used for treating steroid-dependent asthma, for relieving symptoms associated with allergic or nonallergic (vasomotor) rhinitis or for preventing recurrent nasal polyps following surgical removal. It has 500 times the topical anti-infammatory activity of dexamethasone but Beclomethasone (Dipropionate) is less active as a systemic glucocorticoid and is almost inactive by the oral route.


Adult Dose
Dose: 250 to 500 mcg
Single Dose: 380 (375)
Frequency: 12 hourly
Route: Inhalation
Instructions: Frequency may be increased upto 4 times/day if needed.
Neonatal
Dose: 6.25 ug/kg
Single Dose: 6.2 (6.25)
Frequency: 8 hourly
Route: Inhalation
Instructions:
Paedriatic
Dose: 5 to 10 ug/kg
Single Dose: 7.5 (7.5)
Frequency: 8 hourly
Route: Inhalation
Instructions: -
Characteristics
Beclomethasone (Dipropionate) also known as Beclometasone (Dipropionate), Beclometasone (Dipropionate). . It is of Synthetic origin and belongs to Steroid. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Nasal pharmacological group.The Molecular Weight of Beclomethasone (Dipropionate) is 521.00. Its pKa is unionized.
Contraindications
Beclomethasone (Dipropionate) is contraindicated in conditions like Acne,Respiratory tract infections,Pulmonary TB,Ulcers,Rosacea,Perioral dermatitis.
Effects
The severe or irreversible adverse effects of Beclomethasone (Dipropionate), which give rise to further complications include Dermal thinning, Telangiectasia, Striae, Glaucoma, Cataract, Osteoporosis, Increased IOP (intraocular pressure).Beclomethasone (Dipropionate) produces potentially life-threatening effects which include Addisonian crises, Cushing`s syndrome. which are responsible for the discontinuation of Beclomethasone (Dipropionate) therapy.The signs and symptoms that are produced after the acute overdosage of Beclomethasone (Dipropionate) include Hallucinations.The symptomatic adverse reactions produced by Beclomethasone (Dipropionate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Irritation, Oropharyngeal candidiasis, Dysphonia, Epithelial damage, Allergic reactions, Flushing, Sneezing, Xerostomia, Nasal irritation, Dysgeusia.
Indications
Beclomethasone (Dipropionate) is primarily indicated in conditions like Allergic rhinitis, Asthma, Dermatitis, Eczema, Granuloma annulare, Lichen planus, Lichen simplex, Lupus erythematosus, NSAID-associated gastric and duodenal ulcers (prophylaxis), Prophylaxis of asthma, Pruritus ANI, Psoriasis, Vasomotor rhinitis, and can also be given in adjunctive therapy as an alternative drug of choice in Liver transplant.
Interactions
Beclomethasone (Dipropionate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDiazoxideHypotensive effect of Diazoxide antagonised by Beclomethasone.Ketoconazoleketoconazole and itraconazole increase serum-methylprednisolone concentration and enhance methyl prednisolones adrenal suppressive effectsPhenytoin (Na)reduced efficasy of corticosteroids in asthmatic , arthritic, renal and other patients who recieve phenytoin or phenobarbital RifampicinRifampicin reduce the activity of corticosteroids by accelerating their metabolismTechnetium Tc-99m GluceptateUptake of technetium Tc 99m gluceptate in cerebral tumor or abscess may be decreased because of reduced peritumor edema caused by the Beclomethasone (Dipropionate).Technetium Tc-99m OxidronateLong-term therapy with glucocorticoids may induce bone mineral depletion, thus causing decreased bone uptake of technetium Tc 99m oxidronate. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Nasal Spray, Inhaler Store Below 40°C. Do not Freeze. Protect from Sunlight and Moisture.
Warnings
Beclomethasone should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3 months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred.
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