Xipamide

Xipamide is a diuretic and antihypertensive agent. Xipamide is a similar to frusemide but slower onset and longer duration of action. Chemically Xipamide is 5-(aminosulfony)-4-chloro-N (2, 6-dimethylphenyl)-2-hydroxybenzamide. Xipamide is used in control of high blood pressure and in the treatment of fluid over load.

Brands
Adult Dose
Dose: 0.286 mg/kg
Single Dose: 0.29 (0.286)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Sulphonamide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.The Molecular Weight of Xipamide is 354.80. Its pKa is 4.8, 10.0.
Contraindications
Xipamide
Effects
The severe or irreversible adverse effects of Xipamide, which give rise to further complications include Vertigo, Nocturia, Dizziness.Xipamide produces potentially life-threatening effects which include Hypokalemia. which are responsible for the discontinuation of Xipamide therapy.
Indications
Xipamide is primarily indicated in conditions like Edema, Hypertension, Left ventricular failure, Oedema.
Interactions
No data regarding the interactions of Xipamide was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C.
Warnings
Xipamide should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug, causing dizziness or lightheadedness, so limit alcohol intake. It should be used with caution while engaging in activities requiring alertness. This drug changes fluid balance, cause dizziness, if change from a lying to a standing position too rapidly, avoid this by sitting up a few minutes before rising. It should be used with caution during pregnancy or lactation.
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