Vincristine (Sulphate)

'Vincristine (Sulphate) is antineoplastic (anticancer) drug. Vincristine (Sulphate) is alkaloid derivative of Vinca rosea, the periwinkle plant. Structurally Vincristine (Sulphate) is a complexed compound and differ from vinblastine only in having an aldehyde moiety. Vinblastine is an alkaloid extracted from the periwinkle plant. Vincristine (Sulphate) is a parenteral, cell cycle-phase specific antineoplastic agent used in the management of breast carcinoma, bladder carcinoma, Hodgkin''s disease, melanoma, and testicular carcinoma. Vincristine is similar to vinblastine in action, but their toxicities differ significantly. Vincristine was approved by the FDA in 1961. Vincristine (Sulphate) is used in combination of different anticancer drugs to obtain best therapeutic effect and minimize side effects or toxicity.'

Brands
VINCRISTINE VINCRISTINE VINRACINE VINRACINE ONCOVIN PHARMACRISTINE PHARMACRISTINE VINCRISTINA GADOR VINCRISTINE VINCRISTINE
Adult Dose
Dose: 1.4 to 1.5 mg/sq.meter
Single Dose: 1.4 (1.45)
Frequency: As recommended.
Route: IV
Instructions: Once in a Week
Neonatal
Dose: 0.05 mg/kg
Single Dose: 0.05 (0.05)
Frequency: As recommended.
Route: Intravenous
Instructions: Initial once weekly then as required
Paedriatic
Dose: 1 to 2 mg/sq.meter
Single Dose: 1.5 (1.5)
Frequency: As recommended.
Route: Intra Venous
Instructions: Per Week for 3-6 Weeks, As Required
Characteristics
Vincristine (Sulphate) also known as Leurocristine sulphate. . It is of Natural origin and belongs to Alkaloid. It belongs to Mitotic Inhibitors and Antineoplastic Agent, Plant Derivative pharmacological group.The Molecular Weight of Vincristine (Sulphate) is 923.00. Its pKa is 5.0, 7.4.
Contraindications
Vincristine (Sulphate) is contraindicated in conditions like Bronchospasm,Jaundice,Marie tooth syndrome.
Effects
The severe or irreversible adverse effects of Vincristine (Sulphate), which give rise to further complications include GI symptoms, Neurotoxicity.The signs and symptoms that are produced after the acute overdosage of Vincristine (Sulphate) include Myelosuppression.The symptomatic adverse reactions produced by Vincristine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Vomiting, Alopecia, Diarrhea, Fever, Constipation, Weight loss.
Indications
'Vincristine (Sulphate) is primarily indicated in conditions like Acute leukemia, Breast cancer, Hodgkin''s disease, Leukaemia, Lymphomas, Neuroblastoma, Non-hodgkin''s lymphoma, Rhabdomyosarcoma, Solid tumor, Wilms tumor.'
Interactions
Vincristine (Sulphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAllopurinolCoadministration of these agents may enhanced the risk of peripheral neuropathy.ModerateClosely monitor for the symptoms of neuropathy. Reduce the dose or discontinue drug if symptoms of peripheral neuropathy appear.ItraconazoleMitomycin CNifedipineNifedipine inhibit the outward cellular transport of vincristine. Intracellular concentration of vincristine may be increased.MinorClosely monitor the patient for increased effects of vincristine.StavudineTechnetium Tc-99m GluceptateBrain images may show increased activity due to chemotherapeutic neurotoxicity following therapy Vincristine (Sulphate) and Technetium Tc-99m Gluceptate.Tice-BCGVincristine (Sulphate) may increase the risk of serious, life-threatening infections when given concurrently with Tice-BCG.VORICONAZOLEVoriconazole may increase the serum concentration of Vincristine by decreasing its metabolism.Consider alternate therapy to avoid Vincristine toxicityZalcitabineVincristine potentiate the risk of adverse effects of zalcitabine such as peripheral neuropathy.ModerateCombination should be avoided. If concomitant use is necessary Closely monitor for symptoms of neuropathy. Discontinue zalcitabine if neuropathy develop. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in refrigerator.
Warnings
'Vincristine is not recommended for use in pregnant or nursing women. Contraceptive measures are recommended for use in men or women when taking this drug. It can lower body''s ability to fight an infection, consult the doctor if any sign of an infection such as fever, sore throat, rash or chills appear. Do not have immunizations or vaccinations without consent of doctor and avoid contact with people who have recently received oral polio vaccine.'
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