Vinblastine (Sulphate)

'Vinblastine is an antineoplastic (anticancer) agent. Vinblastine (Sulphate) is alkaloid derivative of Vinca rosea, the periwinkle plant. Vinblastine (Sulphate) is a parenteral, cell cycle-phase specific antineoplastic agent used in the management of breast carcinoma, bladder carcinoma, Hodgkin''s disease, melanoma, and testicular carcinoma. Vinblastine is similar to vincristine in action, but their toxicities differ significantly. Vinblastine was approved by the FDA in 1961. Vinblastine (Sulphate) is used in combination of different anticancer drugs to obtain best therapeutic effect and to minimize side effects or toxicity.'

Brands
VELBASTINE VELBE VINBLAS
Adult Dose
Dose: 100 ug/ sq.meter
Single Dose: 180 (183)
Frequency: As recommended.
Route: IV
Instructions: Once in a Week
Neonatal
Paedriatic
Dose: 2.5 to 6 mg/sq.meter
Single Dose: 4.2 (4.25)
Frequency: As recommended.
Route: Intra Venous
Instructions: Once every 1-2 weeks for 3-6 Weeks
Characteristics
. It is of Natural origin and belongs to Alkaloid. It belongs to Mitotic Inhibitors and Antineoplastic Agent, Plant Derivative pharmacological group.The Molecular Weight of Vinblastine (Sulphate) is 909.10. Its pKa is 5.4, 7.4.
Contraindications
Vinblastine (Sulphate)
Effects
The severe or irreversible adverse effects of Vinblastine (Sulphate), which give rise to further complications include GI symptoms.Vinblastine (Sulphate) produces potentially life-threatening effects which include Myelosuppression. which are responsible for the discontinuation of Vinblastine (Sulphate) therapy.The signs and symptoms that are produced after the acute overdosage of Vinblastine (Sulphate) include Myelosuppression, Neurotoxicity.The symptomatic adverse reactions produced by Vinblastine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Diarrhea, Abdominal cramps, Constipation, Paralytic ileus.
Indications
'Vinblastine (Sulphate) is primarily indicated in conditions like Acute leukemia, Histiocytosis, Hodgkin''s disease, Kaposis sarcoma, Lymphomas, Non-hodgkin''s lymphoma, NSAID-associated ulceration, Solid tumor, Testicular cancer.'
Interactions
Vinblastine (Sulphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementFosphenytoinInterferon AlphaMitomycin CTice-BCGVinblastine (Sulphate) may increase the risk of serious, life-threatening infections when given concurrently with Tice-BCG.VORICONAZOLEVoriconazole may decrease the metabolism of VinblastineConsider alternate therapy to avoid Vinblastine toxicity These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store in refrigerator. Protect from Sunlight. Use within 30 days if kept at room temperature.
Warnings
'Vinblastin can lower body''s ability to fight an infection, consult the doctor if any signs of an infection such as fever, sore throat, rash or chills appear. Avoid contact with people with the flu. Do not have immunizations or vaccinations without consent of doctor and avoid contact with people who have recently received oral polio vaccine. Contraceptive (birth control) measures are recommended for use in men and women while taking this medication. It is not recommended for use in pregnant or nursing women. Avoid aspirin, alcohol and citrus juices.'
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