Vigabatrin

Vigabatrin is anticonvulsant agent. Vigabatrin is analogue of GABA (gamma amino-butyric acid). GABA is an inhibitory neurotransmitter, which is thought to be deficient in epilepsy, and able to stabilise discharges from epileptic foci. Vigabatrin is used in treatment of epilepsy, especially when not controlled by other drugs.

Brands
VLEP VLEP VLEP VLEP VLEP VLEP
Adult Dose
Dose: 21.429 to 57.143 mg/kg
Single Dose: 39 (39.286)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Dose: 20 to 50 mg/kg
Single Dose: 35 (35)
Frequency: 12 hourly
Route: Oral
Instructions: -
Characteristics
Vigabatrin also known as Gamma Vinyl Aminobutyric Acid. . It is of Synthetic origin and belongs to Aminohexanoic Acid. It belongs to Gaba transaminase inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antineoplastic Agent pharmacological group.The Molecular Weight of Vigabatrin is 129.60. Its pKa is 4.02, 9.72.
Contraindications
Vigabatrin is contraindicated in conditions like Ventricular arrhythmias resistant to other treatment.
Effects
The signs and symptoms that are produced after the acute overdosage of Vigabatrin include Coma, Unconsciousness, Tremor, Vertigo.The symptomatic adverse reactions produced by Vigabatrin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Irritability, Ataxia, Nervousness, Confusion, Depression, Psychosis, Diplopia, SomnolenceX.
Indications
Vigabatrin is primarily indicated in conditions like Epilepsy, Infantile spasms, and can also be given in adjunctive therapy as an alternative drug of choice in Iron deficiency anaemia.
Interactions
Vigabatrin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementFosphenytoin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature.
Warnings
Vigabatrin should be used with caution during pregnancy. It should be used with caution in elderly and patient with renal (kidney) impairment. Care is required when withdrawing vigabatrin therapy. Caution is warranted in patients with history of psychosis or behavioral problems.
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