Vidarabine (Monohydrate)

Vidarabine (Monohydrate) is adenosine analog. Vidarabine (Monohydrate) is antiviral agent. Vidarabine (Monohydrate) is active against herpes simplex viruses, varicella zoster virus and cytomegalovirus.


Brands
Adult Dose
Dose: 0.833 to 1.25 mg/kg.hr
Single Dose: 1 (1.0415)
Frequency: 24 hourly
Route: IV Inf
Instructions: For 12 Hours in a Day
Neonatal
Paedriatic
Characteristics
Vidarabine (Monohydrate) also known as Ara-A. . It is of Semi Synthetic origin and belongs to Arabinofuranosyladenine. It belongs to DNA polymerase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antiviral Agents pharmacological group.The Molecular Weight of Vidarabine (Monohydrate) is 285.30.
Contraindications
Vidarabine (Monohydrate) is contraindicated in conditions like Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Vidarabine (Monohydrate), which give rise to further complications include Megaloblastic anemia.The signs and symptoms that are produced after the acute overdosage of Vidarabine (Monohydrate) include Thrombocytopenia, Hematopoietic depression.The symptomatic adverse reactions produced by Vidarabine (Monohydrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Ataxia, Anorexia, Diarrhea, Confusion, Hallucination, Tremor, Nausea and vomiting, Phosis.
Indications
Vidarabine (Monohydrate) is primarily indicated in conditions like Herpes simplex infections, Herpes simplex keratitis, Varicella zoster infections.
Interactions
Vidarabine (Monohydrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAllopurinolInterferon AlphaMethotrexateTheophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye Oint Store Below 40°C. Protect from Heat.
Warnings
Vidarabine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any eye problem or allergy, especially to any antibiotic.
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