Vecuronium (Br)

Vecuronium is a skeletal muscle relaxant. Vecuronium (Br) is a competitive neuromuscular blocking agent. itinhibits the transmission at the neuromuscualr junction. During the 16th century, European explorers found that natives of the Amazon Basin of South America were using an arrow poison that produced death by skeletal muscle paralysis. This poison later became the subject of intense investigation. Curare, the active crude materal, formed the basis for some of the earliest scientific studies in pharmacology. The active principle curare from tubocurarine and its synthetic derivative have had a tremendous influence on the practice of anesthesia and surgrey and have been useful also in defining normal neuromuscular physiologic mechanisms.

Brands
VERONIUM VERONIUM NORCURON NORCURON
Adult Dose
Dose: 90 ug/kg
Single Dose: 90 (90)
Frequency: As recommended.
Route: IV
Instructions: Initially for Once
Neonatal
Paedriatic
Dose: 30 to 50 ug/kg
Single Dose: 40 (40)
Frequency: As recommended.
Route: Intravenous
Instructions: Maintenance,as required
Characteristics
. It is of Synthetic origin and belongs to Steroid. It belongs to Cholinergic nicotinic antagonist pharmacological group on the basis of mechanism of action and also classified in Muscle Relaxants and Neuromuscular Blocking Agent, Nondepolarizing pharmacological group.The Molecular Weight of Vecuronium (Br) is 637.70. Its pKa is 8.97.
Contraindications
Vecuronium (Br) is contraindicated in conditions like Obstructive airway disease,GI motality disorder.
Effects
The severe or irreversible adverse effects of Vecuronium (Br), which give rise to further complications include Cardiac arrhythmias, Urticaria, Bronchospasm.The signs and symptoms that are produced after the acute overdosage of Vecuronium (Br) include Reduction in Prothrombin time, Reduction in partial thromboplastin.
Indications
Vecuronium (Br) is primarily indicated in conditions like Muscle relaxation (intermediate duration) for surgery or intubation, Surgical neuromuscular blocker.
Interactions
Vecuronium (Br) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlfentanil (HCl)AzathioprineBambuterolDesfluraneEnfluraneEnflurane potentiates the effect of vecuronium.ModerateDose of vecuronium should be reduced. Only specially trained health care providers should administer enflurane.EtherEtomidateFentanyl (Citrate)Fentanyl (Citrate)HalothaneHalothane potentiate the effect of vecuronium.ModerateDose of vecuronium should be reduced. Halothane should be administer only by specially trained health care providers.IsofluraneKetamine (HCl)Magnesium SulphateMethohexitone (Na)Noradrenaline (Acid Tartrate)Phenytoin (Na)Phenytoin produce resistance to muscle-relaxant effects of vecuronium.ModerateClosely monitor the neuromuscular blockage.Polymyxin B (Sulphate)Potassium ChloridePropofolSufentanil (Citrate)Suxamethonium (Cl)Tetracycline (HCl)TheophyllineThiamine HCl (Vitamin B1)Thiopentone (Na)TobramycinBoth are neuromuscular blocking agents so, concomitant use result in severe or prolonged respiratory depression.MajorClosely monitor the vital signs and adjust the dose of drugs accordingly. Ventilatory support should be readily available in case of respiratory arrest.Verapamil (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature. Protect from Sunlight.
Warnings
Vecuronium should be used with caution in patients with liver or kidney impairment and cardiovascular diseases.
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