Ursodeoxycholic Acid

Ursodeoxycholic Acid is a secondary bile acid formed in the intestine. Ursodeoxycholic Acid is the 7-β-hydroxy epimer of chenodiol (chenodeoxycholic acid). Chemically Ursodeoxycholic Acid is identified as 3a, 7β-dihydroxy-5β-cholan-24-oic acid. Ursodeoxycholic Acid is choleretic and decreases the concentration of cholesterol in bile. Ursodeoxycholic Acid is used to dissolve cholesterol gallstones, also effective for the treatment of primary biliary cirrhosis.

Brands
URSOFALK URSOGAL URSOGAL URSOX TRIPTOR TRIPTOR URSO URSO
Adult Dose
Dose: 420 to 560 mg
Single Dose: 490 (490)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Dose: 4 to 6 mg/kg
Single Dose: 5 (5)
Frequency: 24 hourly
Route: Oral
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Steroid. It belongs to Bile solubiliser (GI) pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.The Molecular Weight of Ursodeoxycholic Acid is 392.60. Its pKa is 5.
Contraindications
Ursodeoxycholic Acid is contraindicated in conditions like Calcified gallstones,Non-functioning gallbladders,Pigment gallstone.
Effects
The symptomatic adverse reactions produced by Ursodeoxycholic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea.
Indications
Ursodeoxycholic Acid is primarily indicated in conditions like Cholestrol gall stones, Dissolution of gallstones, Iron-deficiency anaemia with chronic renal failure.
Interactions
Ursodeoxycholic Acid is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementChenodeoxycholic AcidClomiphene (Citrate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Susp Refrigeration and Freezing is not recommended.
Warnings
Ursodeoxycholic acid should not be administered to patients with chronic liver disease, peptic ulcer or inflammatory bowel disease. Its use should be avoided in pregnancy.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.