UROFIX UROFIX

Dose: 73.333 IU/kg.min
Single Dose: 73 (73.333)
Frequency: As recommended.
Route: IV Inf
Instructions: Maintenance, As Required

. It is of Natural origin and belongs to Polypeptide. It belongs to Plasminogen Activator pharmacological group on the basis of mechanism of action and also classified in Thrombolytic Agent pharmacological group.The Molecular Weight of Urokinase is 33000.00.

Urokinase is contraindicated in conditions like Hypertension,Peptic ulcer,Cardiac stroke,Renal diseases,Liver diseases,Trauma,Bleeding diathesis,Internal haemorrhage.

Urokinase produces potentially life-threatening effects which include Cerebral hemorrhage, Bleeding. which are responsible for the discontinuation of Urokinase therapy.The symptomatic adverse reactions produced by Urokinase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Blood oozing from venopuncture sites.

Urokinase is primarily indicated in conditions like Arterial thrombosis, Hyphaema, Myocardial infarction, Pulmonary embolism, Thrombosis.

Urokinase is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinIncreased risk of severe bleeding.ModerateDuring coadministration, carefully monitor the signs of bleeding.Heparin (Na) and Heparin (Cl)HyaluronidaseTenecteplaseConcurrent use is usually not recommended but may be required in some cases. If both medicines are prescribed together, change of dose may be required. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store in refrigerator.

Before starting therapy with urokinase determine hematocrits, platelets counts, thrombin time, prothrombin time, activated partial thromboplastin time, fibrinogen levels.