Urea (Topical)

Urea is formed in the liver through the urea cycle from ammonia. Urea (Topical) is the principal end product of the protein catabolism and constitutes about one half of the total urinary solids. Pharmaceutically, Urea (Topical) is used in creams as an emollient, which soften and moisturize the skin and reduce excess scaling and also used to protect the skin against irritation (chafing, diaper rash).

Brands
NUTRIDERMIS NUTRIDERMIS URODERM DREAM-18
Adult Dose
Dose: 10%
Single Dose: 10 (10)
Frequency: 12 hourly
Route: Topical
Instructions: As Required
Neonatal
Paedriatic
Characteristics
Urea (Topical) also known as Carbamide. . It is of Synthetic origin and belongs to Organic Compound. It belongs to Dermatological-Moisturiser pharmacological group on the basis of mechanism of action and also classified in Dermatological Products pharmacological group.The Molecular Weight of Urea (Topical) is 60.06. It is weakly acidic drug, 1.63% solution of the drug is isotonic and Its pKa is 0.2.
Contraindications
Urea (Topical) is contraindicated in conditions like Bacterial infections,Fungal infection,Viral infection.
Effects
The symptomatic adverse reactions produced by Urea (Topical) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Irritation, Burning, Skin eruptions.
Indications
Urea (Topical) is primarily indicated in conditions like Dry skin, Eczema, Onychomycoses, Pruritus, Psoriasis, Skin ulceration, Slack hairy tounge.
Interactions
Urea (Topical) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementLypressinVasopressin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased level of Blood urea nitrogen (BUN) concentrations
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Lotion, Cream Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Urea may be used with caution during pregnancy or lactation. It should be used with caution in patients with any skin infection, skin disorder or sensitive to any topical lotions or creams or if have any allergy.
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