Tryptophan

Tryptophan is amino acid. Chemically it is an amino- β-3-indole propionic acid, existing in proteins. Tryptophan is essential for optimal growth in infants and for nitrogen equilibrium in human adults. Adequate level in diet may compensate the deficiencies of Niacin and thus mitigate pellagra.


Adult Dose
Dose: 1 to 6 g
Single Dose: 3.5 (3.5)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin and belongs to Amino Acid. It belongs to Serotonin precursor pharmacological group on the basis of mechanism of action and also classified in Antipsychotic Agent pharmacological group.The Molecular Weight of Tryptophan is 204.20. It is strongly acidic drug and Its pKa is 2.4, 9.4.
Contraindications
Tryptophan is contraindicated in conditions like Diabetes mellitus,Cancer,Scleroderma,Achlorhydic states.
Effects
Tryptophan produces potentially life-threatening effects which include Eosinophilia, Myalgia. which are responsible for the discontinuation of Tryptophan therapy.The symptomatic adverse reactions produced by Tryptophan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Anorexia.
Indications
Tryptophan is primarily indicated in conditions like Depression, Insomnia, Mania, Nausea and vomiting (acute attacks), Obesity, Obsessive-compulsive disorders, Pain, Psychosis, and can also be given in adjunctive therapy as an alternative drug of choice in Myoclonic seizures.
Interactions
Tryptophan is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementEscitalopramContraindicatedFluoxetine (HCl)IsocarboxazidParoxetine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Protect from Sunlight and Moisture.
Warnings
Patients should observe caution while driving or performing other tasks requiring alertness, because it may produce drowsiness. It is recommended that patient receiving tryptophan should be closely monitored, with particular care being paid to eosinophil count, hematological changes and muscles symptomatology.
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