Triprolidine (HCl)

Triprolidine (HCl) is antihistamine. Triprolidine (HCl) is effective in the symptomatic treatment of seasonal and perennial allergic rhinitis, allergic conjunctivitis and uncomplicated skin manifestation of urticaria etc.


Adult Dose
Dose: 25 to 50 mg
Single Dose: 38 (37.5)
Frequency: 8 hourly
Route: PO
Instructions: Frequency may be increased upto 4 times/day if needed.
Neonatal
Dose: 0.125 mg/kg
Single Dose: 0.12 (0.125)
Frequency: 8 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 0.2 mg/kg
Single Dose: 0.2 (0.2)
Frequency: 8 hourly
Route: Oral
Instructions: -
Characteristics
Triprolidine is the derivative of Triprolidine (HCl). It is of Synthetic origin and belongs to Pyridine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Triprolidine (HCl) is 332.90. Its pKa is 3.6, 9.3.
Contraindications
Triprolidine (HCl) is contraindicated in conditions like Alcohol dependence,Prostatic hypertrophy,Narrow-angle glaucoma,Hypersensitivity.
Effects
The signs and symptoms that are produced after the acute overdosage of Triprolidine (HCl) include Convulsions, Respiratory depression, Dizziness, Incoordination, Weakness.The symptomatic adverse reactions produced by Triprolidine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Anorexia, Palpitation, Tinnitus, Blurred vision, Confusion, Epigastric discomfort, Dysuria, Photosensitivity, Postural hypotension, Skin eruptions, SomnolenceX, Urinary frequency, GI disturbance, Lassitude.
Indications
Triprolidine (HCl) is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis, Angioedema, Angiooedema, Common cold, Fever, Urticaria.
Interactions
Triprolidine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholClemastineDipipanone (HCl)GlycopyrrolateSodium AcetateAlkalization of the urine decreases the urinary excretion increases the elimination half-life of Triprolidine (HCl).ModeratePatients should be monitored for toxic effects such as tremor, anxiety, insomnia, irritability, or nervousness. Dosage reductions may be required. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Syrup Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Triprolidine should be used with caution in patients with asthma, glaucoma, ulcer, difficulty urinating due to an enlarged prostate gland, heart disease, high blood pressure, seizures or hyperthyroidism. Do not drink alcoholic beverages. This drug should be used only if clearly needed during pregnancy or lactation. Do not give this medication to a child younger than six years of age unless directed to do so by a doctor.
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