Dose: 0.714 to 1.071 mg/kg
Single Dose: 0.89 (0.8925)
Frequency: 24 hourly
Route: PO
Instructions: -

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

. It is of Synthetic origin and belongs to Tricyclic Ammonium. It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Trimipramine (Maleate) is 410.50. Its pKa is 7.72.

Trimipramine (Maleate) is contraindicated in conditions like Cardiac arrhythmia,Mania,Myocardial infarction,Liver diseases,Narrow-angle glaucoma.

The severe or irreversible adverse effects of Trimipramine (Maleate), which give rise to further complications include Agitation.Trimipramine (Maleate) produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia, Jaundice. which are responsible for the discontinuation of Trimipramine (Maleate) therapy.The signs and symptoms that are produced after the acute overdosage of Trimipramine (Maleate) include Drowsiness, Dry mouth, Dilated pupils, Sinus tachycardia.The symptomatic adverse reactions produced by Trimipramine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Tremors, Constipation, Abdominal pain, Dry mouth, Rashes, Sedation, Postural hypotension, Light headedness, Increased intracranial pressure.

Trimipramine (Maleate) is primarily indicated in conditions like Anxiety, Depression, Insomnia, Peptic ulcer, and can also be given in adjunctive therapy as an alternative drug of choice in Digestive disorder.

Trimipramine (Maleate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholBethanidine (Sulphate)Clonidine (HCl)Debrisoquine (Sulphate)EphedrineGuanethidineMethyldopaMethylphenidate (HCl)Phenylephrine (HCl)Rauwolfia ReserpineVORICONAZOLEVoriconazole may increase the serum concentration of trimipramine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects Vortioxetineincreases the toxicity of vortioxetineuse alternative These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store Below 40°C. Protect from Sunlight and Moisture.

Trimepramine should be used with caution in patients with glaucoma, prostate problems, decreased urine output, thyroid disease, breathing problems, seizure problems, alcohol use, heart disease, mental or emotional problems, liver or kidney disease and of any drug allergy. It should be used caution while driving or engaging in tasks requiring alertness such as operating machinery. Limit alcohol consumption as it may increase the drowsiness and dizziness effects of this drug. Limit exposure to hot weather as it may lead to heat stroke. This drug should be used during pregnancy or lactation only if clearly needed.