ALBROTRAN ALBROTRAN ALBROTRAN ALBROTRAN SULFARIM SULFARIM SULFARIM SULFARIM PRIMOX PRIMOX PRIMOX PRIMOX ANTRIMA ANTRIMA ANTRIMA BOSCHTRIM BOSCHTRIM OSTRIN OSTRIN FORTE SULFORIN SULFORIN PABTRAN EFTRAN EFTRAN DS COTRIZOLE COTRIZOLE SEPTROZOLE SEPTROZOLE SEPTROZOLE SEPTROZOLE SEPTROZOLE D.S SEPTROZOLE D.S BECTY FLOCOT FLOCOT BIOTRAN BIOTRAN BIOTRAN SEPTRAN SEPTRAN SYRAPRIM TRIMOXIN TRIMOXIN-DS MEXAZOL MEXAZOL ASCOTRAN HICOT HICOT PULCORIDE PULCORIDE PULCORIDE SURFADINE SURFADINE SURFADINE CO-TRIMAX CO-TRIMAX CO-TRIMAX CO-TRIMAX KAYTRAN KAYTRAN KAYTRAN SULPHATRAN SULPHATRAN SULPHATRAN SULPHATRAN SULPHATRAN D.S. NOVOZOLE NOVOZOLE NOVOZOLE XA-ZOLE XA-ZOLE XA-ZOLE FORTE MACTRAN MACTRAN MACTRAN MACTRAN COMAX COMAX COMAX TRIMEX TRIMEX AMTRIL AMTRIL AMTRIL AMTRIL AMTRIL AMTRIL TRISEP TRISEP TRISEP OBITRAN OBITRAN LONGASAL LONGASAL LONGASAL OPIRAN COLITRAN COLITRAN COLITRAN BACTIPRONT BACTIPRONT PHARTEX PHARTEX PHARTEX-DS PHARTEX-DS FAKZOL FAKZOL FAKZOL FAKZOL THERASEPT THERASEPT THERASEPT B.D. DUTRAN TRANAZOL D.S TRANAZOL D.S TRANAZOL TRANAZOL TRANAZOL TRANAZOL NICOTRIM FORTE BACTRIM BACTRIM SAYDETRON PLAIN SUPRACOMBIN SUPRACOMBIN SEMOZOL SEMOZOL NILIUM COTRIZA COTRIZA FORTE COTRI COTRI-DD SILTRAN SILTRAN SILTRAN INFECTRAN INFECTRAN NICOTRIM SAYDETRON SAYDETRON AMOXAZOL COBACT MAZATRIM MAZATRIM MAZATRIM MEPEDRIN MEPEDRIN SULPHADIAZINE MB-TRAN MB-TRAN POLYTRAN POLYTRAN SUPTREX SUPTREX SUPTREX SEPTAZOLE SEPTAZOLE SEPTAZOLE SEPTAZOLE SEPTAZOLE SEPTAZOLE BACITRAN BACITRAN BACITRAN BACTY FORTE BACTY FORTE BACTY FORTE DOSATRAN DOSATRAN DOSATRAN DOSATRAN FEDRAN OCTIL-S OCTIL-S OCTIL-S OCTIL-S OCTIL-S OCTIL-S PENETRIN WILTRAN WILTRAN WILTRAN WILTRAN WILTRAN COTRAY COTRAY COTRAY MOXOTRIM MOXOTRIM MOXOTRIM BIPRIM BIPRIM BIPRIM BIPRIM CHEMIZOL CHEMIZOL CHEMIZOL COTRIGEN COTRIGEN COTRIGEN FERROTRAN FERROTRAN TRIZOL TRIZOL IMCOTRAN TXAZOLE TXAZOLE COTRIMOXAZOLE COTRIMOXAZOLE COTRIMOXAZOLE COTRIMOXAZOLE COTRIMOXAZOLE CHEMORTAN CHEMORTAN CHEMORTAN CHEMORTAN SAPTRI COTRIMOXAZOLE COTRIMOXAZOLE ZEPTRA ZEPTRA AKSOTRAN AKSOTRAN COZOL COZOL ZOLEBID BACTRIM FORTE BACTRIM FORTE BIPRIM FORTE BIOTRAN FORTE BIOTRAN FORTE SEPTRAN DS SEPTRAN DS DECTRON SULFA-X SULFA-X SULFA-X TRIMEX FORTE TRIMEX FORTE TRIMEX P TRIMEX P BACTIPRONT DUPLEX PAKZOLE PAKZOLE NICOTRIM PAED COTRIMOXAZOLE COTRIMOXAZOLE SEPTATONE PEAD LOBACT LOBACT FORTE EROPRIM SULPHA EROPRIM SULPHA EROPRIM SULPHA ORGASTRAN ORGASTRAN FORTE XA-ZOLE DS BACTRIZOLE DS SEMOZOL DS ROYAMAX SUPRACOMBIN FORTE QAMTRAN UNITRAN UNITRAN COTRIMOXAZOLE COTRIMOXAZOLE COTRIMOXAZOLE COTRIMOXAZOLE MAZATRIM FORTE COTRIMOXAZOLE PLAIN COTRIMOXAZOLE PLAIN CO-SEPT RASCOTRAN RASCOTRAN RASCOTRAN RASCOTRAN SMARTRIM SMARTRIM COTRIMAXAL COTRIMAXAL SOSETRAM SOSETRAM SOSETRAM SOSETRAM SOSETRAM SOSETRAM SINERSEL SINERSEL SINERSEL SULPRIM SULPRIM WINOTRIM FORTE AMTRAN AMTRAN AMTRAN AMTRAN COTRIM COTRIM CARTRIUM DS CARTRIUM DS KOTRIA KOTRIA DS KOTRIA DS STAIMXZOL STAIMXZOL INCOT-DS ZOPRIM ZOPRIM-DS EIPTRAN EIPTRAN EIPTRAN EIPTRAN FORTE METHAX TRICARE BITRA SEFT SEFT Kepinol Forte

Dose: 300 mg
Single Dose: 300 (300)
Frequency: 24 hourly
Route: PO
Instructions: For 7-Days

Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 12 hourly
Route: Oral
Instructions:

Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 12 hourly
Route: Oral
Instructions: -

. It is of Synthetic origin and belongs to Pyrimidine. It belongs to Dihydrofolate reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Trimethoprim is 290.30. Its pKa is 7.3.

Trimethoprim is contraindicated in conditions like Impaired renal function,Haematological disorders.

The signs and symptoms that are produced after the acute overdosage of Trimethoprim include Vomiting, Depression, Psychosis, Mania, Facial edema.

Trimethoprim is primarily indicated in conditions like Benign gastric and duodenal ulceration and chronic gastritis, Prophylaxis of NSAID-induced gastric and duodenal ulceration, Prophylaxis of UTI, Respiratory tract infections, UTI.

Trimethoprim is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmantadine (HCl)Renal clearance of amantadine is decrease by trimethoprim result in increase risk of mental confusion due to increase in serum amantadine levels. Minorpatient shoulb be monitor for side effects related to nervous system on coadministration this cobination.AzathioprineCoadministration increases the risk of bone marrow supression,thrombocytopenia and neutropenia in renal transplant patient.ModerateClose clinical monitoring for hematological adverse effects is recommended during and after therapy.BendrofluazideClozapineColistin (Sulphate & Sulphomethate Na)Cyclosporin ATrimethoprim decreases the efficacy of cyclosporin.Combined use may increase the serum creatinine level.ModerateClosely monitor the renal function of patient and efficacy and safety of both drugs. An alternative antibiotic may be use.DapsoneDigoxinGanciclovir (Na)GlipizideHydrochlorothiazideLamivudineLamivudineMetformin (HCl)Trimethoprim reduces the excretion of metformin by competing for renal tubular transport results in increased level of metformin may lead to lactic acidosis.ModerateSlowly reduce the dose of metformin. Closely monitor the blood glucose level. Patient should notify to physician if experience signs of lactic acidosis.MethotrexateCoadministration enhance thre risk of severe myelosuppression and megoblastic anemia due to synergistic effect involving folate antagonism.MajorCoadministration generally be avoided. If given then close monitoring for hematologic toxicity is recommended.NorgestimatePara Aminobenzoic AcidShould not be used concurrently except on medical advice.Phenytoin (Na)PyrimethaminePyrimethamineRifampicinSilver SulphadiazineSulfadoxineSulphadiazineSulphamethoxazoleWarfarin (Na)Trimethoprim may decrease the metabolism of Warfarin.ModerateMonitor for increased effects of Warfarin if Trimethoprim is initiated/dose increased, and decreased effects if Trimethoprim is discontinued/dose decreased. ZalcitabineZidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store Below 40°C.

Trimethoprim should be used with caution in patients with kidney disease, any anemia or any drug allergy. Trimethoprim should be used during pregnancy only if clearly needed. Avoid use during lactation.