Trimetaphan (Camsylate)

Trimethaphan is a sulfonium competitive nicotinic ganglionic blocking agent with direct vasodilator action. It has a very short duration of action. Trimetaphan (Camsylate) is used as an antihypertensive to produce controlled hypotension during surgery and for the emergency treatment of hypertensive crisis and pulmonary edema due to hypertension. Historically drugs that block stimulation of post-ganglionic autonomic neurons by acetylcholine were among the first agents used in the treatment of hypertension. Most such drugs are no longer available clinically because of intolerable toxicities related to their primary action. Until recently, trimethaphan was still used to treat hypertension. However, in 1996 it was withdrawn from the market. Trimetaphan (Camsylate) is administered by intravenous infusion.

Brands
Adult Dose
Dose: 0.07 to 0.086 mg/kg.min
Single Dose: 0.078 (0.078)
Frequency: As recommended.
Route: IV Inf
Instructions: As Required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Dibenzyloxoimidazol. It belongs to Cholinergic nicotinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Trimetaphan (Camsylate) is 596.80.
Contraindications
'Trimetaphan (Camsylate) is contraindicated in conditions like Addison''s disease,Pyloric disease,Arteriosclerosis.'
Effects
The severe or irreversible adverse effects of Trimetaphan (Camsylate), which give rise to further complications include Asthma.Trimetaphan (Camsylate) produces potentially life-threatening effects which include Respiratory arrest. which are responsible for the discontinuation of Trimetaphan (Camsylate) therapy.The signs and symptoms that are produced after the acute overdosage of Trimetaphan (Camsylate) include Tachycardia.
Indications
Trimetaphan (Camsylate) is primarily indicated in conditions like Hypertension, Hypertensive emergencies, Induce hypotension, Myocardial infarction, Prophylaxis of NSAID-induced duodenal ulcer, and can also be given in adjunctive therapy as an alternative drug of choice in Surgery.
Interactions
Trimetaphan (Camsylate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementPropiomazineConcurrent use of Trimetaphan (Camsylate) with propiomazine may potentiate the hypotensive response, with increased risk of severe hypotension, shock, and cardiovascular collapse during surgery.Suxamethonium (Cl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Ampuls Store in refrigerator. Do not Freeze.
Warnings
Trimetaphan should be used with great caution in elderly patients, in children or in allergic individuals. Monitor respiratory status closely.
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