Trimeprazine (Tartrate)

Trimeprazine (Tartrate) is a phenothiazine similar to chlorpromazine. Trimeprazine (Tartrate) is used as an antiemetic, sedative and antipruritic agent. Trimeprazine (Tartrate) is used in urticaria and for prolong relief of pruritic symptoms in a variety of allergic and non-allergic conditions.

Brands
COTRIMOXAZOLE COTRIMOXAZOLE
Adult Dose
Dose: 0.19 mg/kg
Single Dose: 0.19 (0.19)
Frequency: 8 hourly
Route: PO
Instructions: -
Neonatal
Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 8 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 8 hourly
Route: Oral
Instructions: -
Characteristics
Trimeprazine (Tartrate) also known as Alimemazine Tartrate. . It is of Synthetic origin and belongs to Phenothiazine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Trimeprazine (Tartrate) is 747.00. Its pKa is 9.2.
Contraindications
Trimeprazine (Tartrate) is contraindicated in conditions like Epilepsy,Glucoma,Myasthenia gravis,Parkinsonism,Prostatic hypertrophy.
Effects
The severe or irreversible adverse effects of Trimeprazine (Tartrate), which give rise to further complications include Hypoglycemia.Trimeprazine (Tartrate) produces potentially life-threatening effects which include Respiratory depression, Hypotension, Malignant hyperpyrexia. which are responsible for the discontinuation of Trimeprazine (Tartrate) therapy.The signs and symptoms that are produced after the acute overdosage of Trimeprazine (Tartrate) include Tachycardia, Respiratory failure, Hypoventilation, Extrapyramidal effects, Anticholinergic effects.The symptomatic adverse reactions produced by Trimeprazine (Tartrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Dry mouth, Depression, Nasal congestion, Galactorrhea, Vivid dreams, Photosensitive dermatitis, Abdominal discomfort.
Indications
Trimeprazine (Tartrate) is primarily indicated in conditions like Allergy, Insomnia, Premedication in anaesthesia, Pruritus, Urticaria, Urticaria and pruritus.
Interactions
Trimeprazine (Tartrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCitalopram (HBr)MolindoneConcurrent use with Molindone increases certain serious side effects.NeostigminePyridostigmine (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Cap, Syrup Store Below 25°C. Protect from Sunlight.
Warnings
Trimeprazine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer S/C because irritation or lesion may occur.
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