Treosulfan

Treosulfan is antineoplastic (anticancer) agent, related to busulphan. it used in the treatment of ovarian cancer. Treosulfan is metabolized by liver and converted into epoxide form, which is the active form of the drug. It acts by demagining the DNA and thus interfering with cell replication. Treosulfan is used in combination with different anticancer drugs to achieve best therapeutic results and to reduce toxicity or side effects.

Brands
Adult Dose
Dose: 3.571 mg/kg
Single Dose: 3.6 (3.571)
Frequency: 6 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Characteristics
Treosulfan also known as Dihydroxybusulphan. . It is of Synthetic origin and belongs to Methane Sulphonate. It belongs to Alkylating Agents pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Alkylating Agent pharmacological group.The Molecular Weight of Treosulfan is 278.30. Its pKa is not relevant.
Contraindications
Treosulfan
Effects
The severe or irreversible adverse effects of Treosulfan, which give rise to further complications include Myelosuppressive effect.Treosulfan produces potentially life-threatening effects which include Bone marrow suppression, Myelogenous leukemia. which are responsible for the discontinuation of Treosulfan therapy.The symptomatic adverse reactions produced by Treosulfan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Stomatitis, Nausea and vomiting, Thrombocytopenia, Skin pigmentation.
Indications
Treosulfan is primarily indicated in conditions like Ovarian cancer.
Interactions
No data regarding the interactions of Treosulfan was found.
Interfrence
Risks
Drug should not be given to Paediatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Cap, IV Inj, IV Inf
Warnings
No data regarding the Warnings/Precuations of Treosulfan is available.
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