Dose: 2.86 to 8.57 mg/kg
Single Dose: 5.7 (5.715)
Frequency: 8 hourly
Route: PO
Instructions: -

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

. It is of Synthetic origin and belongs to Pyrrole. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Tolmetin (Na) is 315.30. Its pKa is 3.5.

Tolmetin (Na) is contraindicated in conditions like Peptic ulcer.

Tolmetin (Na) produces potentially life-threatening effects which include Agranulocytosis, Renal failure, Hepatic failure. which are responsible for the discontinuation of Tolmetin (Na) therapy.The symptomatic adverse reactions produced by Tolmetin (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Nausea, Vomiting, Diarrhea, Tinnitus, Rashes, Weight gain, Edema, Hearing loss, Weight loss, Hypertension, GI disturbance.

Tolmetin (Na) is primarily indicated in conditions like Ankylosing spondylitis, Osteoarthritis, Pain, Pre-articular disorder, Rheumatoid arthritis.

Tolmetin (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementMethotrexateTolmetin increases the plasma concentration of methotrexate by interfering with renal elimination results in increased toxicity and pharmacological effects.MajorClosely monitor for signs of bone marrow suppression and nephrotoxicity. Avoid any other over-the-counter NSAID product. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Test for Proteinuria by acid Precipitation Method

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Caps Store Below 40°C. Protect from Sunlight and Moisture.

Tolmetin should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory (hearing) function test during chronic therapy. Discontinue drug if skin reaction occurs.