Dose: 0.1 to 0.71 mg/kg
Single Dose: 0.41 (0.405)
Frequency: 4 hourly
Route: IM
Instructions: -

Dose: 0.016 to 0.033 mg/kg.min
Single Dose: 0.024 (0.0245)
Frequency: As recommended.
Route: IV Infusion
Instructions: Maintenance , as required

Tolazoline (HCl) also known as Benzozoline HCl. . It is of Synthetic origin and belongs to Imidazole. It belongs to Alpha adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Vasodilators pharmacological group.The Molecular Weight of Tolazoline (HCl) is 196.70. Its pKa is 10.4.

Tolazoline (HCl) is contraindicated in conditions like Angina,Myocardial infarction,Shock,GI ulceration,Hypotension,Cerebrovascular accident,Mitral stenosis.

The severe or irreversible adverse effects of Tolazoline (HCl), which give rise to further complications include Nausea, Vomiting, Thrombocytopenia, Leucopenia, Sweating, Apprehension, Shivering.Tolazoline (HCl) produces potentially life-threatening effects which include Severe Hypotension, Cardiac arrhythmias, Shock. which are responsible for the discontinuation of Tolazoline (HCl) therapy.The symptomatic adverse reactions produced by Tolazoline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flushing, Piloerection.

Tolazoline (HCl) is primarily indicated in conditions like Peripheral vascular disease, Pulmonary hypertension.

Tolazoline (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholClonidine (HCl)Dopamine (HCl)Dopamine (HCl)Noradrenaline (Acid Tartrate)Ranitidine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Ampuls Store at room temperature. Protect from Sunlight.

Where vital signs, as oxygenation, acid-base status, fluid and electrolytes can be monitored and maintained, use tolazoline in a highly supervised setting. It should not be use in patients with ischaemic heart disease, hypotension, peptic ulcer.