Tocainide (HCl)

Tocainide (HCl) is investigational anti-arrhythmic agent. Chemically Tocainide (HCl) is a 2-amino-N-(2, 6-dimethylphenyl) propanamide. Tocainide (HCl) is a homologue of the desethyl metabolite of lidocaine. Tocainide (HCl) is resistant to first pass metabolism. its antiarrhythmic action is similar to that of lidocaine.

Brands
Adult Dose
Dose: 8.57 to 11.43 mg/kg
Single Dose: 10 (10)
Frequency: 8 hourly
Route: PO
Instructions: Maintenance, As Required
Neonatal
Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Primary Amine. It belongs to Na-Channel Antiarrhythmic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.The Molecular Weight of Tocainide (HCl) is 228.70. Its pKa is 7.7.
Contraindications
Tocainide (HCl) is contraindicated in conditions like Av block of ii &iii degree.
Effects
The severe or irreversible adverse effects of Tocainide (HCl), which give rise to further complications include Lupus erythematosus, Pulmonary fibrosis, Pulmonary edema, Pneumonitis, Interstitial pneumonitis, Fibrosing alveolitis.Tocainide (HCl) produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia, Blood dyscrasias, Aplastic Anemia, Leucopenia, Aggravation of ventricular arrhythmias. which are responsible for the discontinuation of Tocainide (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Tocainide (HCl) include Convulsions, Respiratory depression, Excitation, Cardiovascular disturbances.The symptomatic adverse reactions produced by Tocainide (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, SweatingX, Convulsions, Visual hallucinations.
Indications
Tocainide (HCl) is primarily indicated in conditions like Myocardial infarction, Ventricular arrhythmias.
Interactions
No data regarding the interactions of Tocainide (HCl) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Tocainide should be used with caution in patients of liver or kidney diseases because the rate of elimination may be significantly decreased. Correct any potassium deficit because tocainide is ineffective in hypokalemia.
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