ABBOCIN ABBOCIN TOBRADEX TOBRADEX TOBREX TOBREX EYEBREX EYEBREX TOBRACIN BROMYCIN BROMYCIN BROMYCIN-D BRULAMYCIN BRULAMYCIN TOBRAXIA NEO-BREX NEO-BREX TOBCIN TOBCIN TOBCIN SANTOBREX SANTOBREX SANTODEX SANTODEX ORBACIN TOBRACIN INJ TOBRACIN INJ TOMA NEBRA NEBRA OCUTOB-DEX CINDEX TOBRIN TOBRA TOBRA-D AMGYDEX AMGYDEX DEXATOB OTOTOB OBRAMYCIN OBRAMYCIN AMGY BRACIN BRACIN BRULACIL BRULACIL BRULACIL BRULACIL OPHTH-TOBRA OPHTH-TOBRA-D OPHTH-TOBRA-D EYEBRADEX MAGRACIN MEBRADEX DICON EYE DROPS TOBRACIN-D TOCIN TOCIN BRACIN-D TOBRASONE TODEX OPTIBRAM NEBCIN NEBCIN NEBCIN NEBCIN OBRADEX OBREX BROMOREX BROMOREX BROMOREX BROMOREX REVICURE BRADEX MYRET TOBRADON TOBRADON TRANCE KLOZEN MORCIN NABROD NABROD NABROD DEXADRON T MYDEX ORCYDEX MYNOSIDE MYNOSIDE MYNOSIDE OCUCID OCUTOB ORCY MINOSIDE VEGATOB MYTOBRA TOBRAMET MQOBRA OCUTODEX LOTEPRED-T TOBCY TOBCY TOBCYDEX

Dose: 3 to 5 mg/ kg
Single Dose: 4 (4)
Frequency: As recommended.
Route: IM,Slow IV
Instructions: In 3-4 divided doses.

Dose: 2 to 2.5 mg/kg
Single Dose: 2.2 (2.25)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: -

Dose: 2 to 2.5 mg/kg
Single Dose: 2.2 (2.25)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: -

Tobramycin Sulphate is the derivative of Tobramycin. It is of Semi Synthetic origin and belongs to Aminoglycosides. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action. The Molecular Weight of Tobramycin is 467.50. Its pKa is 6.7, 8.3, 9.9.

Tobramycin is contraindicated in conditions like Hypersensitivity.

The severe or irreversible adverse effects of Tobramycin, which give rise to further complications include Ototoxicity, Elevation in serum creatinine, Neuromuscular blockage.Tobramycin produces potentially life-threatening effects which include Nephrotoxicity, Dehydration, Proteinuria, Oliguria, Hyperuricemia. which are responsible for the discontinuation of Tobramycin therapy.The symptomatic adverse reactions produced by Tobramycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin reactions, Maculopapular rash, Urticaria, Local pain, Phlebitis.

'Tobramycin is primarily indicated in conditions like Bacterial infections, Biliary tract infections, Chronic pulmonary pseudomonas aeruginosa infection in cystic fibrosis patients, Cystic fibrosis, Endocarditis, Eye infections, Gram +ve (some) and gram -ve (many) infections, Heart failure, Iron deficiency anaemia, NSAID-associated ulceration, Oliguria due to renal failure, Pneumonia in hospital patients, Prohylaxis of stress ulceration, Respiratory tract infections, Septicaemia, Supraventricular arrhythmias (particularly atrial fibrillation), Symptoms associated with carcinoid tumours, Trauma, Ulcerative colitis and crohn''s disease, Urinary tract infection, UTI.'

Tobramycin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAtracurium (Besylate)Coadministartoin results in severe respiratory depression by decreasing the release of acetylcholine at neuromuscular junction by interfering with calcium influx.MajorCoadministration must be avoided. Vital signs should closely monitored and dose adjustment is necessary.Calcium GluconateCarbenicillin (Na)Cefaclor (Monohydrate)coadministration increase nephrotoxicityCefotaximesynergestic effect for pseudomonas aeruginosaCephaloridineCephradineCisplatinEthacrynic AcidFrusemide or FurosemideFrusemide may enhance the adverse/toxic effect of Tobramycin. Specifically, nephrotoxicity and ototoxicity. ModerateMonitor for toxic effects of Tobramycin if Furosemide is initiated or the dose is increased. This is probably of most concern if Furosemide is administered in high doses for extended periods of time.GentamicinRespiratory paralysis and renal dysfunction risk is increased if this combination is used.MajorThis combination should be avoided.Piperacillin (Na)Polymyxin B (Sulphate)Tubocurarine (Cl) Both are neuromuscular blocking agents so, concomitant use result in severe or prolonged respiratory depression.MajorClosely monitor the vital signs and adjust the dose of drugs accordingly. Ventilatory support should be readily available in case of respiratory arrest.Vancomycin (HCl)Vecuronium (Br)Both are neuromuscular blocking agents so, concomitant use result in severe or prolonged respiratory depression.MajorClosely monitor the vital signs and adjust the dose of drugs accordingly. Ventilatory support should be readily available in case of respiratory arrest. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Eye Drops, Oint, Inj Store at room temperature or refrigerator. Protect from Sunlight.

Tobramycin should be used with caution in patients with history of kidney diseases, vertigo, hearing loss, myasthenia gravis, parkinsonisms. It should be used with caution in patients who are sensitive to aminoglycosides. Perform monthly blood counts test for atleast 4 months. Keep patients well hydrated to prevent chemical irritation or nephrotoxic reactions. Take appropriate measures in case of secondary infections.