Tinidazole

Tinidazole is antimicrobial agent. Tinidazole is used for prevention of post-operative anaerobic and acute gum infections.


Adult Dose
Dose: 2 g
Single Dose: 2 (2)
Frequency: 24 hourly
Route: PO
Instructions: Initial dose.
Neonatal
Dose: 50 to 75 mg/kg
Single Dose: 62 (62.5)
Frequency: 24 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 50 to 75 mg/kg
Single Dose: 62 (62.5)
Frequency: 24 hourly
Route: Oral
Instructions: -
Characteristics
belongs to Imidazole. It belongs to Antibiotic (Prokaryote DNA) pharmacological group on the basis of mechanism of action and also classified in Amebicides pharmacological group.The Molecular Weight of Tinidazole is 247.00. Its pKa is 1.81.
Contraindications
Tinidazole
Effects
Tinidazole produces potentially life-threatening effects which include Hypotension, Dyspnea, Bronchospasm, Facial edema, Laryngeal edema. which are responsible for the discontinuation of Tinidazole therapy.The symptomatic adverse reactions produced by Tinidazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Urticaria, Thrombophlebitis, Metallic taste.
Indications
Tinidazole is primarily indicated in conditions like Abdominal surgery prophylaxis, Acute leukemia, Amoebiasis, Anaerobic infections, Giardiasis, NSAID-associated ulceration, Prophylaxis of acid aspiration in obstetric patients, Trichomoniasis, Upper gastro-intestinal and breast cancer.
Interactions
No data regarding the interactions of Tinidazole was found.
Interfrence
Interferes with determinations of AST,SGOTInterferes with determinations of ALT,SGPT
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 25°C. Protect from Sunlight and Moisture.
Warnings
Tinidazol should be used with caution in patients with any allergy. Avoid use during pregnancy or lactation. Avoid alcoholic beverages while taking this medication as severe stomach upset, nausea, vomiting, headache and flushing can occur.
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