Ticarcillin (di Na)

Ticarcillin is a carboxypenicillin antibiotic. Penicillin is derived directly or indirectly from strains of fungi of the genus Penicillium and other soil inhabiting fungi grown on special culture media. Penicillins are active against most bacteria especially gram positive pathogen (streptococci, staphylococci, pneumococci), some negative starins (gonococci, meningoccocci), some spirochetes and some fugi. The structure of penicillin consists of a thiazolidine ring connected to a β lactam ring, which is attached to a side chain. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Ticarcillin (di Na) is important to take the drug for the full time period as prescribed. Discontinuation of the drug, may result in ineffective treatment.

Brands

TIMENTIN TIMENTIN

Adult Dose

Dose: 71.43 to 95.24 mg/kg
Single Dose: 83 (83.335)
Frequency: 8 hourly
Route: Slow IV
Instructions: -

Neonatal

Dose: 50 to 75 mg/kg
Single Dose: 62 (62.5)
Frequency: 6 hourly
Route: Intramuscular
Instructions:

Paedriatic

Dose: 50 to 75 mg/kg
Single Dose: 62 (62.5)
Frequency: 6 hourly
Route: Intra Muscular
Instructions: -

Characteristics

. It is of Semi Synthetic origin and belongs to Penicillanic Acid. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Ticarcillin (di Na) is 428.40. Its pKa is 2.44, 3.64.

Contraindications

Ticarcillin (di Na)

Effects

The severe or irreversible adverse effects of Ticarcillin (di Na), which give rise to further complications include Nephrotoxicity, Thrombocytopenia, Ototoxicity, Neutropenia, Neurotoxicity, Platelet dysfunction.Ticarcillin (di Na) produces potentially life-threatening effects which include Anaphylactoid reactions. which are responsible for the discontinuation of Ticarcillin (di Na) therapy.The symptomatic adverse reactions produced by Ticarcillin (di Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Phlebitis, Glossitis, Nausea and vomiting, Oral moniliasis.

Indications

Ticarcillin (di Na) is primarily indicated in conditions like Anaerobic infections, Bacterial infections, Infections due to pseudomonas aeruginosa, proteus spp. and bacteroides fragilis, Respiratory tract infections, Septicaemia, UTI.

Interactions

No data regarding the interactions of Ticarcillin (di Na) was found.

Interfrence

Risks

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

IV Inj (reconstituted soln) Store at room temperature or refrigerator. Freezing is recommended. Protect from Sunlight.

Warnings

Ticarcillin should be used with caution in patients with any other illness or any allergy especially to penicillin or other antibiotics. It should be used only if clearly needed during pregnancy or lactation.

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