Tiaprofenic Acid

Tiaprofenic Acid is NSAID ( non steroidal antinflammatory drug), similar to ibuprofen. It reduces inflammation and fever and relieves pain. Tiaprofenic Acid is also used in the treatment of arthritis, headaches and menstrual cramps.


Brands
Adult Dose
Dose: 300 mg
Single Dose: 300 (300)
Frequency: 12 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Propionic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Tiaprofenic Acid is 260.30. Its pKa is 3.0.
Contraindications
Tiaprofenic Acid is contraindicated in conditions like Peptic ulcer,Renal diseases.
Effects
Tiaprofenic Acid produces potentially life-threatening effects which include Hemorrhage, Agranulocytosis, Renal failure, Hepatic failure. which are responsible for the discontinuation of Tiaprofenic Acid therapy.The signs and symptoms that are produced after the acute overdosage of Tiaprofenic Acid include Nausea, Epigastric pain.The symptomatic adverse reactions produced by Tiaprofenic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Skin rashes, Gastritis, SweatingX, Nausea and vomiting, Heart burn, Paresthesias.
Indications
Tiaprofenic Acid is primarily indicated in conditions like Ankylosing spondylitis, Musculoskeletal disorders, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Rheumatoid arthritis.
Interactions
No data regarding the interactions of Tiaprofenic Acid was found.
Interfrence
Zimmerman Reaction
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Cap Store Below 30°C. Protect from Sunlight.
Warnings
Avoid use in patients with prior history of urinary symptoms and discontinue at first sign of genitourinary problems. Severe cases of cystitis (bladder pain, dysuria, urinary frequency, hematuria) due to tiaprofenic acid have been reported. Safety and efficacy have not been established in pediatric patients. Elderly are at a high risk for adverse effects from NSAIDs. As many as 60% of elderly can develop peptic ulceration and/or hemorrhage asymptomatically.
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