THYRAXINIL THYORIN THYROXINE SODIUM THYROXINE SODIUM THYROXINE THYRO THYROX THYROTEX THYRIL T4 THYRONORM THYRONORM THYRONORM THYRONORM THYRONORM

Dose: 50 to 100 ug
Single Dose: 75 (75)
Frequency: 24 hourly
Route: PO
Instructions: Initially for 2 Weeks

Dose: 6 to 8 mg/kg
Single Dose: 7 (7)
Frequency: 24 hourly
Route: Oral
Instructions:

Dose: 5 ug/kg
Single Dose: 5 (5)
Frequency: 24 hourly
Route: Oral
Instructions: -

Thyroxine (Na) also known as Levothyroxine (Na). . It is of Natural origin and belongs to Tyrosine. It belongs to Thyroxine agonsit pharmacological group on the basis of mechanism of action and also classified in Thyroid Hormone pharmacological group.The Molecular Weight of Thyroxine (Na) is 798.90. It is weakly alkaline drug and Its pKa is 2.2, 6.5, 10.1.

Thyroxine (Na) is contraindicated in conditions like Angina,Cardiac failure,Pituitary disease,Adrenal failure.

The severe or irreversible adverse effects of Thyroxine (Na), which give rise to further complications include Sinus tachycardia, Diarrhoea, Tachycardia, Cardiac arrhythmias, Insomnia, Weight loss, Agitation, Tremors, Heat intolerance.Thyroxine (Na) produces potentially life-threatening effects which include Myocardial infarction, Exacerbation of angina, Exacerbation of cardiac arrhythmias. which are responsible for the discontinuation of Thyroxine (Na) therapy.The signs and symptoms that are produced after the acute overdosage of Thyroxine (Na) include Coma, Hyperpyrexia, Cardiovascular collapse, Thyrotoxicosis.The symptomatic adverse reactions produced by Thyroxine (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Irritability, Alopecia, Anorexia, Diaphoresis, Amenorrhea, Atrial fibrillation.

Thyroxine (Na) is primarily indicated in conditions like Acquired hypothyroidism, Congenital hypothyroidism, Cretinism, Hypothyroidism, Myxedema coma, Non-toxic goiter.

Thyroxine (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmiodarone (HCl)CarbamazepineCarbamazepine accelerates metabolism of Theophylline (reduced effect).ChloroquineCholestyramineCholestyramineEthylestrenolIron SaltsKetamine (HCl)Phenylbutazone Phenytoin (Na)Sevelamer HClincreased thyroid stimulating hormone (TSH) levels have been reported in patients co-administered sevelamer hydrochloride and levothyroxineclose monitoring is recommendedSodium Polystyrene SulphonateSucralfateSucralfateTestosterone (Esters)Trifluoperazine (HCl)Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Test for Hypothyroidism

Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store in a well closed container, Below 40°C. Protect from Sunlight.

Thyroxine should be used with caution in patients with heart problems, diabetes, adrenal gland problems or of any allergy, including drug allergies. Avoid using thyroid drugs for weight control. Current information shows that this drug may be used during pregnancy. It should be used with caution during lactation.