PENTOTHAL SODIUM THIOPEN THIOPENTONE BITOL SODIUM THIONOL M-PENTONE M-PENTONE THIOPENTAL THIOPTONE

Dose: 250 to 5000 mg
Single Dose: 2600 (2625)
Frequency: As recommended.
Route: IV
Instructions: As Required

Dose: 2 to 7 mg/kg
Single Dose: 4.5 (4.5)
Frequency: As recommended.
Route: Intra Venous
Instructions: Single Dose

Dose: 2 to 7 mg/kg
Single Dose: 4.5 (4.5)
Frequency: As recommended.
Route: Intra Venous
Instructions: Single Dose

belongs to Thiobarbiturate. It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action and also classified in General Anesthetics pharmacological group.The Molecular Weight of Thiopentone (Na) is 264.30. It is weakly alkaline drug, 3.50% solution of the drug is isotonic and Its pKa is 7.6.

Thiopentone (Na) is contraindicated in conditions like Porphyria.

Thiopentone (Na) produces potentially life-threatening effects which include Apnea, Respiratory depression, Hypotension, CNS depression, Myocardial depression. which are responsible for the discontinuation of Thiopentone (Na) therapy.The symptomatic adverse reactions produced by Thiopentone (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Cough, Bronchospasm, Laryngospasm, Hiccough.

Thiopentone (Na) is primarily indicated in conditions like Convulsions, Induction of anaesthesia, Induction of general anaesthesia, Reduction of raised intracranial pressure, and can also be given in adjunctive therapy as an alternative drug of choice in Cerebral ischaemia.

Thiopentone (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAspirinCyclizineHydromorphoneMethylphenidate (HCl)Nitrous OxidePethidine (HCl)Phenytoin (Na)ProbenecidPromethazine (HCl)Promethazine (HCl)Sufentanil (Citrate)SulfadoxineSulfisoxazoleVecuronium (Br)Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store in refrigerator. Protect from Sunlight. Rectal suppositories Store at room temperature.

Exercise caution in patients with impaired function of respiratory, circulatory, kidney, liver or endocrine system. Avoid extravascular and intra-arterial injection of thiopentone because it may cause pain, swelling, ulceration, necrosis and gangrene of extremities respectively.