Thioguanine

Thioguanine is antineoplastic\anticancer drugs. Thioguanine is structural analogue of naturally occuring purine, guanine, both used by cells for DNA synrhesis. It belongs to a class of antimetabolite, with actions and uses similar to that of mercaptopurine. Antimetabolite are the compound that bear a structural similarity to a natutally occuring substance, such as vitamin, nucleoside or amino acid. Thioguanine is used chiefly in the treatment of lymphoblastic leukemia. Thioguanine is usually given in combination with other anticancer drugs to obtain better results and minimize side effects or toxicity. Thioguanine is administered orally. It was approved by FDA in 1966.

Brands
THIOGUANINE
Adult Dose
Dose: 100 mg/ sq.meter
Single Dose: 180 (183)
Frequency: 12 hourly
Route: PO
Instructions: Over 3-5 days in conjunction with other cytotoxic drugs.
Neonatal
Dose: 1.65 mg/kg
Single Dose: 1.6 (1.65)
Frequency: 12 hourly
Route: Oral
Instructions: For 4 days
Paedriatic
Dose: 1 to 2 mg/kg
Single Dose: 1.5 (1.5)
Frequency: 12 hourly
Route: Oral
Instructions: For 5----7 days
Characteristics
Thioguanine also known as 6-TG. . It is of Synthetic origin and belongs to Thiopurines. It belongs to Antimetabolites (DNA acting) pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agnet, Antimetabolite pharmacological group.The Molecular Weight of Thioguanine is 167.20. Its pKa is 8.1.
Contraindications
Thioguanine
Effects
The severe or irreversible adverse effects of Thioguanine, which give rise to further complications include Thrombocytopenia, Hepatotoxicity, Leucopenia, GI symptoms, Prolongation of clotting time, Anaemia.Thioguanine produces potentially life-threatening effects which include Bone marrow suppression. which are responsible for the discontinuation of Thioguanine therapy.
Indications
Thioguanine is primarily indicated in conditions like Acute leukemia, Chronic myeloid leukaemia, Myeloblastic leukemia.
Interactions
No data regarding the interactions of Thioguanine was found.
Interfrence
Liver Function Test (LFT)
Risks
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Thioguanine is not recommended for use in pregnant or nursing women. Contraceptive (birth control) measures are recommended for use in men or women while taking this medication.
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