Thiacetazone

Thioacetazone is an an anti tuberculous agent and is used to treat tuberculousis (T.B), as an alternative para-aminosalicylic acid.


Adult Dose
Dose: 2.14 mg/kg
Single Dose: 2.1 (2.14)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Characteristics
Thiacetazone also known as Amithiozone, Amithiozone. . It is of Synthetic origin and belongs to Benzaldehyde / Thiosemicarbazone. It belongs to Antimycobacterial agent pharmacological group on the basis of mechanism of action and also classified in Antituberculous Drugs pharmacological group.The Molecular Weight of Thiacetazone is 236.30.
Contraindications
Thiacetazone is contraindicated in conditions like Hepatic failure.
Effects
The severe or irreversible adverse effects of Thiacetazone, which give rise to further complications include Nausea, Vomiting, Diarrhoea, Anemia, Anemia, Thrombocytopenia, Abdominal pain, Agranulocytosis, Anemia.Thiacetazone produces potentially life-threatening effects which include Stevens Johnson syndrome, Toxic epidermal necrolysis. which are responsible for the discontinuation of Thiacetazone therapy.The symptomatic adverse reactions produced by Thiacetazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Ataxia, Blurred vision, VertigoX, Seizures and convulsions, Salivation, Deafness, Epilepsy, Cerebral edema.
Indications
Thiacetazone is primarily indicated in conditions like Acute leukemia, Tuberculosis.
Interactions
No data regarding the interactions of Thiacetazone was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tabs Store . Protect from Sunlight, Moisture and Heat.
Warnings
It is very important that your doctor or health care worker check your progress at regular visits. Tell your doctor immediately if blurred vision or loss of vision, with or without eye pain, occurs during treatment . Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking this medicine. Also, the regular use of alcohol may keep this medicine from working properly. Therefore, you should strictly limit the amount of alcoholic beverages you drink while you are taking this medicine.This medicine may cause a very serious rash in any patient, but it occurs more often in patients with human immunodeficiency virus (HIV) infection. If you notice a rash, stop taking this medicine and see your health care worker immediately.
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