Thiabendazole

Thiabendazole is a broad spectrum anthelmintic agent. Thiabendazole is a benzimidazole compound. It has vermicidal activity against roundworm, whipworm and hookworm. It also has anti-infalmmatory properties, antipyretic, mild antifungal and scabicidal actions.

Brands
Adult Dose
Dose: 25 mg/kg
Single Dose: 25 (25)
Frequency: 12 hourly
Route: PO
Instructions: -
Neonatal
Dose: 25 mg/kg
Single Dose: 25 (25)
Frequency: 12 hourly
Route: Oral
Instructions: -
Paedriatic
Dose: 25 mg/kg
Single Dose: 25 (25)
Frequency: 12 hourly
Route: Oral
Instructions: -
Characteristics
belongs to Imidazole. It belongs to Fumarate reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anthelmintics pharmacological group.The Molecular Weight of Thiabendazole is 201.30. Its pKa is 4.7.
Contraindications
Thiabendazole is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
Thiabendazole produces potentially life-threatening effects which include Stevens Johnson syndrome, Jaundice. which are responsible for the discontinuation of Thiabendazole therapy.The symptomatic adverse reactions produced by Thiabendazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Nausea, Vomiting, Anorexia, Tinnitus, Blurred vision, Pruritus, Elevated hepatic transaminases, Leukopenia, Paresthesias, GI irritation.
Indications
Thiabendazole is primarily indicated in conditions like Helminth infection.
Interactions
Thiabendazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAminophyllineOxtriphylline (Choline Theophyllinate)TheophyllineTheophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Abnormal LFTs
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Susp Store Below 25°C. Protect from Sunlight.
Warnings
Thiabendazole should be used with caution in patients with kidney or liver disease. Patient should observe caution while driving or performing tasks requiring alertness.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.