Testosterone (Esters)

Testosterone is the primary androgen found in the body. Endogenous testosterone is synthesized by cells in the testis, ovary, and adrenal cortex. Therapeutically, testosterone is used in the management of hypogonadism, either congenital or acquired. Testosterone is also the most effective exogenous androgen for the palliative treatment of carcinoma of the breast in postmenopausal women. Testosterone (Esters) is also used to treat menstrual disorder, breast cancer, postpartum breast pain and for suppression of lactation.


Adult Dose
Dose: 200 mg
Single Dose: 200 (200)
Frequency: As recommended.
Route: IM
Instructions: Maintenance, Every 3rd Week
Neonatal
Dose: Not applicable in this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Not applicable in paeds
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
Testosterone Undecanoate is the derivative of Testosterone (Esters). It is of Natural origin and belongs to Steroid. It belongs to Aldosterone agonist pharmacological group on the basis of mechanism of action and also classified in Sex Hormones pharmacological group.The Molecular Weight of Testosterone (Esters) is 288.40.
Contraindications
Testosterone (Esters) is contraindicated in conditions like Heart failure,Prostatic cancer,Pregnancy.
Effects
The severe or irreversible adverse effects of Testosterone (Esters), which give rise to further complications include Skin rashes, Masculinization, Breathing difficulty.Testosterone (Esters) produces potentially life-threatening effects which include Hepatic carcinoma. which are responsible for the discontinuation of Testosterone (Esters) therapy.The signs and symptoms that are produced after the acute overdosage of Testosterone (Esters) include Fluid retension, Polycythemia, Anxiety.The symptomatic adverse reactions produced by Testosterone (Esters) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Vomiting, Jaundice, Depression, Sleeplessness, Edema, Acne, Gynecomastia, Decline in testis size, Supression of spermatogenesis, GI disorders.
Indications
Testosterone (Esters) is primarily indicated in conditions like Androgen deficiency, Breast cancer, Hormone replacement therapy, Infertility, Menopausal symptoms, Micropenis, Muscle weakness.
Interactions
Testosterone (Esters) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCyclosporin AImipramine (HCl)Thyroxine (Na)Warfarin (Na)Testosterone may enhance the anticoagulant effect of Warfarin. ModerateRapidMonitor for increased therapeutic effects of Warfarin if Testosterone is initiated/dose increased, or decreased effects if Testosterone is discontinued/dose decreased. Significant reductions in Warfarin dosage may be needed during concomitant therapy. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Older Urinary Tests for Aldosterone and 17-OH-Corticosteroids Plasma and Serum Tests for Corticosteroids
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight, Moisture and Heat.
Warnings
Testosterone should be used with caution in patients with any disease, especially cancer of the prostate or breast, liver, heart, kidney disease, allergy, enlarged prostate. High dosage, long term use of androgens has been related to liver cancer. This drug should not be used during pregnancy or lactation. Females should be monitored for signs of virilization, such as deepening of the voice, facial hair, acne, menstrual irregularity or clitoral enlargement, consult the doctor promptly if any of these symptoms occur. Use in children should not be recommended due to the possibility this drug may have undesirable effects related to the growth of the child. It should be use with extreme caution in geriatric men because they are at higher risk for developing enlarged prostates or prostate cancer when using this medication.
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