Terbutaline

Terbutaline is oral and parenteral bronchodilator. Terbutaline is one of several sympathomimetic agents that act by selectively stimulating β 2-adrenergic receptors. Clinically, its main use is in the treatment of bronchospasm, although Terbutaline is also effective in delaying premature labor. Terbutaline is available in many dosage forms. It was first approved by the FDA in 1974. its final patent expired in March 1994.


Adult Dose
Dose: 0.25 to 0.5 mg
Single Dose: 0.38 (0.375)
Frequency: 6 hourly
Route: IM,SC,Slow IV
Instructions:
Neonatal
Paedriatic
Dose: 0.05 to 0.15 mg/kg
Single Dose: 0.1 (0.1)
Frequency: 8 hourly
Route: Oral
Instructions:
Characteristics
belongs to Phenylaminoethanol. It belongs to Beta-2 adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Bronchodilator pharmacological group.The Molecular Weight of Terbutaline is 274.30. Its pKa is 8.8, 10.1, 11.2.
Contraindications
Terbutaline is contraindicated in conditions like Thyrotoxicosis,Ischaemic heart disease,Haemorrhage,Taxaemia.
Effects
The severe or irreversible adverse effects of Terbutaline, which give rise to further complications include Ventricular tachycardia.Terbutaline produces potentially life-threatening effects which include Pulmonary edema. which are responsible for the discontinuation of Terbutaline therapy.The signs and symptoms that are produced after the acute overdosage of Terbutaline include Tachycardia, Cardiac arrhythmias, Hypokalemia, Hyperglycemia.The symptomatic adverse reactions produced by Terbutaline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Anxiety, Palpitation, Tremors, Muscle cramps.
Indications
Terbutaline is primarily indicated in conditions like Asthma, Bronchitis, Emphysema, Obstructive airway disease, Oedema, Oliguria due to renal failure, Premature labour, Uncomplicated premature labor, and can also be given in adjunctive therapy as an alternative drug of choice in Acute leukemia, Lymphomas.
Interactions
Terbutaline is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementBendrofluazideFrusemide or FurosemideTerbutaline may enhance the hypokalemic effect of Furosemide. ModerateMonitor for increased risk of hypokalemia, and the associated effects (eg, cardiac conduction problems) in patients receiving concomitant therapy with Terbutaline and Furosemide. Patients with low baseline serum potassium concentrations are likely at increased risk of negative effects. MetipranololInfrequent reports of METIPRANOLOL [EYE] reducing the BRONCHODILATOR effect of TERBUTALINE. MajorPancuronium (Br)Theophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Inhaler, Inj Store at room temperature, Below 30°C. Protect from Sunlight.
Warnings
Avoid intraneural or intravascular injection of terbutaline.
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