Temazepam

Temazepam is oral benzodiazepine used as a hypnotic agent in the short-term management of insomnia.Temazepam is often preferable to flurazepam for insomnia, particularly in the elderly or patients with liver disease, because it has a shorter half-life and does not have active metabolites. It was approved by the FDA in 1981.

Brands
RESTORIL RESTORIL HYPNOTIL HYPNOTIL XTEEM SLEEPAM CALM CALM PAMEASE RESTOMED RESTOMED EZIRIL EZIRIL TEZAM
Adult Dose
Dose: 10 to 40 mg
Single Dose: 25 (25)
Frequency: 24 hourly
Route: PO
Instructions: At bed time.
Neonatal
Dose: 0.5 to 1 mg/kg
Single Dose: 0.75 (0.75)
Frequency: As recommended.
Route: Oral
Instructions: As Required
Paedriatic
Dose: 0.5 to 1 mg/kg
Single Dose: 0.75 (0.75)
Frequency: As recommended.
Route: Oral
Instructions: As Required
Characteristics
. It is of Synthetic origin and belongs to Benzodiazepine. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Sedatives and Hypnotics and Benzodiazepine pharmacological group.The Molecular Weight of Temazepam is 300.70. Its pKa is 1.6.
Contraindications
Temazepam is contraindicated in conditions like Pulmonary insufficiency.
Effects
The severe or irreversible adverse effects of Temazepam, which give rise to further complications include Hypotension, Jaundice, Blood dyscrasias.The symptomatic adverse reactions produced by Temazepam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nystagmus.
Indications
Temazepam is primarily indicated in conditions like Insomnia, Nausea, vertigo, labyrinthine disorders, Premedication before surgery, and can also be given in adjunctive therapy as an alternative drug of choice in Surgery.
Interactions
No data regarding the interactions of Temazepam was found.
Interfrence
Abnormal LFTs
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Administer temazepam with caution in severely depressed patients. Limit repeated prescriptions without adequate medical supervision
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