Suramin

Suramin is antitrypanosomal and antifungal agent. Suramin is effective against parasites Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense and Onchocerca volvulus. Suramin is in the investigational phase for use as an anticancer drug for the treatement of acute leukemia.


Brands
Adult Dose
Dose: 1.43 to 2.86 mg/kg
Single Dose: 2.1 (2.145)
Frequency: As recommended.
Route: IV
Instructions: Initially for Once
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Characteristics
Suramin also known as Antrypol. . It is of Synthetic origin and belongs to Naphthaleinesulphonic Acid. It belongs to Antiparasitic pharmacological group on the basis of mechanism of action and also classified in Antiparasitic pharmacological group.The Molecular Weight of Suramin is 1429.00.
Contraindications
Suramin is contraindicated in conditions like Renal failure,Debility.
Effects
The severe or irreversible adverse effects of Suramin, which give rise to further complications include Nausea, Vomiting, Fever, Renal damage, Urticaria, Thrombocytopenia, Stomatitis, Abdominal pain, Jaundice, Leucopenia, Mucosal ulceration, Adrenal insufficiency.Suramin produces potentially life-threatening effects which include Nausea, Vomiting, Unconsciousness, Shock. which are responsible for the discontinuation of Suramin therapy.The symptomatic adverse reactions produced by Suramin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Constipation, Urticaria, SweatingX, Skin eruptions, Polyarthritis.
Indications
Suramin is primarily indicated in conditions like AIDS, Onchoceriasis, Trypanosomiasis.
Interactions
No data regarding the interactions of Suramin was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in a well closed container. Protect from Sunlight.
Warnings
Avoid use suramin in elderly patients or in patients with severe liver or kidney disease. Suramin should be administered under close medical supervision and general condition of patients improved as far as possible before treatment starts. The urine should be tested before treatment starts and at weekly intervals during treatment, dose should be reduced if moderate proteinuria develops and discontinued if it becomes severe.
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