Sulphacetamide

Sulphacetamide is a synthetic sulfonamide antibiotic for ophthalmic or topical administration. Sulfacetamide, because Sulphacetamide is water soluble and because a 30% solution has a pH of 7.4, is an ideal sulfonamide for ophthalmic administration. Despite the favorable pharmaceutical properties, use of sulfonamides in general has declined due to development of resistance.


Adult Dose
Dose: 10 to 30 %
Single Dose: 20 (20)
Frequency: 6 hourly
Route: Ophthalmic
Instructions:
Neonatal
Paedriatic
Dose: 10 to 20 %
Single Dose: 15 (15)
Frequency: As recommended.
Route: Opthalmic
Instructions: As Required
Characteristics
Sulphacetamide also known as Sulfacetamide. Sulphacetamide Sodium is the derivative of Sulphacetamide. It is of Synthetic origin and belongs to Sulphonamide. It belongs to Dihyropteroate synthetase inhibitor pharmacological group on the basis of mechanism of action and also classified in Dermatological Products and Antibacterial pharmacological group.The Molecular Weight of Sulphacetamide is 254.20. It is weakly alkaline drug, 3.85% solution of the drug is isotonic and Its pKa is 5.78.
Contraindications
Sulphacetamide is contraindicated in conditions like Herpes simplex infections,Renal failure,Corneal infection.
Effects
The severe or irreversible adverse effects of Sulphacetamide, which give rise to further complications include Conjunctivitis, Skin rashes, Corneal plaques.Sulphacetamide produces potentially life-threatening effects which include Stevens Johnson syndrome, Erythema multiforme. which are responsible for the discontinuation of Sulphacetamide therapy.The symptomatic adverse reactions produced by Sulphacetamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Blurred vision, Burning, Vaginal irritation, Stinging on application.
Indications
Sulphacetamide is primarily indicated in conditions like Blepharitis, Conjuctivitis, Eye infections, Vaginosis.
Interactions
No data regarding the interactions of Sulphacetamide was found.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye Oint or Eye Soln, Skin Lotion Store in a well closed container, at room temperature, Below 15°C. Refrigeration and Freezing is not recommended. Protect from Sunlight.
Warnings
Consult with doctor about use of sulphacetamide during pregnancy or lactation.
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