Sulindac

Sulindac is NSAID, non-steroidal antinflammatory drug. It also possesses analgesic and antipyretic properties. Sulindac is a sulfoxide and is structurally related to Indomethacin. Sulindac is a prodrug, effective only when Sulindac is converted to a sulfide by liver enzymes. It relieves pain and reduces fever and inflammation.

Brands

Adult Dose

Dose: 1.43 to 2.86 mg/kg
Single Dose: 2.1 (2.145)
Frequency: 24 hourly
Route: PO
Instructions: -

Neonatal

Dose: Should not be used in this age group
Single Dose:
Frequency:
Route:
Instructions:

Paedriatic

Dose: SAfety not established
Single Dose:
Frequency:
Route:
Instructions:

Characteristics

. It is of Synthetic origin and belongs to NSAID (non-steroidal anti-inflammatory drug). It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents and NSAIDs pharmacological group.The Molecular Weight of Sulindac is 356.42. Its pKa is 4.7.

Contraindications

Sulindac is contraindicated in conditions like Peptic ulcer,GI hemorrhage.

Effects

Sulindac produces potentially life-threatening effects which include Blood dyscrasias, GI bleeding, Allergic reactions. which are responsible for the discontinuation of Sulindac therapy.The symptomatic adverse reactions produced by Sulindac are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Constipation, Abdominal pain, Rashes, Pruritus.

Indications

Sulindac is primarily indicated in conditions like Acute gout, Ankylosing spondylitis, Gout, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Periarticular disorder, Rheumatoid arthritis.

Interactions

Sulindac is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinAspirin decreases the plasma concentration of sulindac. Aspirin may displace sulindac from plasma protein binding site results in increased concentration of unbound, or free, drug available for clearence.ModerateDuring concomitant therapy, patient should take medication with food.Cyclosporin ADiflunisalDimethyl Sulfoxide These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interfrence

Liver Function Test (LFT)

Risks

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Tab Store Below 40°C. Protect from Sunlight and Moisture.

Warnings

Sulindac should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory function test during chronic therapy. Discontinue drug if skin reaction occurs.

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