Sucralfate

Sucralfate is aluminium-sucrose complex, is a sulphated disaccharide developed for the treatment of peptic ulcer. It protects layer on gastro-duodenal mucosa by forming a complex with pepsin which adhere to active ulcers.


Adult Dose
Dose: 1 g
Single Dose: 1 (1)
Frequency: 6 hourly
Route: PO
Instructions:
Neonatal
Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Glucofructose. It belongs to Antacids and Ulcer Healing pharmacological group.
Contraindications
Sucralfate
Effects
The symptomatic adverse reactions produced by Sucralfate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Constipation.
Indications
Sucralfate is primarily indicated in conditions like Benign gastric and duodenal ulceration and chronic gastritis, Duodenal ulcer, Peptic ulcer, Prophylaxis of stress ulceration, Reflux oesophagitis, and can also be given in adjunctive therapy as an alternative drug of choice in Benign gastric and duodenal ulceration, Inflammatory bowel disease.
Interactions
Sucralfate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCimetidine (HCl)Cimetidine (HCl)CiprofloxacinClodronateDiclofenac (K)Diclofenac (Na)DigoxinFosphenytoinKetoconazoleLansoprazoleMoxifloxacinSucralfate releases aluminium ions in the stomach and thereby reduces the absorption of moxifloxacin.Nalidixic AcidOfloxacinOxolinic AcidSucralfate reduce(s) absorption of Oxolinic acidPhenytoin (Na)QuinidineRanitidineSulpirideTetracycline (HCl)TheophyllineThyroxine (Na)Thyroxine (Na)Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Susp Store at room temperature. Freezing is recommended. Tab Store in a well closed container, at room temperature.
Warnings
Do not take antacids 30min before and after sucralfate. Avoid use in patients with renal impairment. It should be used in pregnancy if clearly needed.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.