Streptozotocin

Streptozotocin is antineoplastic antibiotic derived from Streptomyces achromogenes or produced by chemical synthesis. Streptozotocin is the drug of choice in the of treatment of malignant pancreatic insulinomas and malignant carcinoid tumors (especially when given along with Fluorouracil). Streptozotocin is also effective in the treatment of Hodgkin`s disease and for colon cancer, when used in combination with other anticancer drugs.

Brands
Adult Dose
Dose: 500 mg/sq.meter
Single Dose: 920 (916)
Frequency: 24 hourly
Route: IV
Instructions: For 5 Days
Neonatal
Paedriatic
Characteristics
Streptozotocin also known as Streptozocine. . It is of Synthetic origin and belongs to Glucopyranose. It belongs to DNA Strand Breakage pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Streptozotocin is 265.20.
Contraindications
Streptozotocin is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Streptozotocin, which give rise to further complications include Gi bleeding, Confusion, Pulmonary fibrosis, Increased intracranial pressure, Myocardial infarction, Brain neoplasm.Streptozotocin produces potentially life-threatening effects which include Bone marrow suppression, Renal failure, Hepatic failure, Perforation of large intestine. which are responsible for the discontinuation of Streptozotocin therapy.The symptomatic adverse reactions produced by Streptozotocin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Alopecia, Diarrhea, Fever, Urticaria, Hypotension, Tremor, Thrombophlebitis, StomatitisX, Slurred speech, Skin ulcers, Limb paresthesia.
Indications
Streptozotocin is primarily indicated in conditions like Islet cell pancreatic tumor, Pancreatic cancer.
Interactions
Streptozotocin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDoxorubicin (HCl)The toxicity may be increased if streptozotocin is given concurrentlyMajorFluorouracilPhenytoin (Na)StreptomycinConcurrent use may cause toxicities to the kidneys. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store at room temperature or refrigerator. Protect from Sunlight. Use within 12 hrs if kept at room temperature.
Warnings
Streptozotocin is not recommended for use during pregnancy or lactation. Immunosuppressent drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes, and should not be inhaled. Avoid use in patient with impaired kidney or liver function.
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