Streptokinase

Streptokinase is a nonenzymatic protein produced by group C β-hemolytic streptococci. Clinically, Streptokinase is used as a parenteral thrombolytic agent in the management of acute myocardial infarction, pulmonary embolism, deep vein thrombosis, occluded arteriovenous cannulae, and acute arterial thrombosis and embolism. Unlike urokinase, repeated administration of it can result in tolerance and/or hypersensitivity. Streptokinase is considerably less expensive than other thrombolytics.

Brands
AKINASE STREPTASE UNITINASE DURAKINASE AMIKASE KABIKINASE STREPTOFACTOR ESKINASE STREPTOKINASE DICLAIR-ST
Adult Dose
Dose: 250000 IU
Single Dose: 250000 (250000)
Frequency: As recommended.
Route: IV
Instructions: Load for 30 min.
Neonatal
Dose: 8.33 to 16.66 ug/kg.min
Single Dose: 12 (12.495)
Frequency: As recommended.
Route: IV Infusion
Instructions: Maintenance, As Required
Paedriatic
Dose: 8.33 to 16.66 ug/kg.min
Single Dose: 12 (12.495)
Frequency: As recommended.
Route: IV Infusion
Instructions: Maintenance, As Required
Characteristics
Streptokinase also known as Plasminokinase. . It is of Natural origin and belongs to Protein. It belongs to Plasminogen Activator pharmacological group on the basis of mechanism of action and also classified in Thrombolytic Agent pharmacological group.The Molecular Weight of Streptokinase is 47408.00.
Contraindications
Streptokinase is contraindicated in conditions like Hypertension,Peptic ulcer,Cardiac stroke,Trauma,Bleeding diathesis.
Effects
Streptokinase produces potentially life-threatening effects which include Bleeding, Allergic reactions. which are responsible for the discontinuation of Streptokinase therapy.The signs and symptoms that are produced after the acute overdosage of Streptokinase include Hemorrhage.The symptomatic adverse reactions produced by Streptokinase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fever, Chills, Nausea and vomiting, Rigors.
Indications
Streptokinase is primarily indicated in conditions like Acute myocardial infarction, Arterial thrombosis, Deep vein thrombosis, Desloughing wounds, Duodenal ulcer and gastric ulcer, Myocardial infarction, Prophylaxis of NSAID-associated gastric or duodenal ulcer, Pulmonary embolism, Thrombosis.
Interactions
Streptokinase is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinIncreased risk of bleeding.ModerateCarefully monitor the signs of bleeding, during coadministration.Heparin (Na) and Heparin (Cl)TenecteplaseConcurrent use is usually not recommended but may be required in some cases. If both medicines are prescribed together, change of dose may be required. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Hematocrit Value Decreased plasminogen levelDecreased fibrinogen level
Risks
Drug should not be given to Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store in refrigerator. Use within 8 hrs if kept at room temperature.
Warnings
Before starting therapy with streptokinase determine hematocrits, platelets counts, thrombin time, prothrombin time, activated partial thromboplastin time, fibrinogen levels.
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