Stilboestrol

Stilboestrol is a synthetic hormone. Stilboestrol is used as a contraceptive. Stilboestrol is used to treat symptoms associated with menopause. It may also be used to prevent osteoporosis (bone loss), amenorrhea, abnormal uterine bleeding and to inhibit growth of prostate and breast cancer

Brands
Adult Dose
Dose: 0.01 to 0.04 mg/kg
Single Dose: 0.025 (0.025)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Dose: Not indicated in children
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Not indicated in children
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
Stilboestrol also known as Diethyl Stilbestrol, Diethyl Stilbestrol. . It is of Synthetic origin and belongs to Stilbene. It belongs to Oestrogen Agonist pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent pharmacological group.The Molecular Weight of Stilboestrol is 268.40.
Contraindications
Stilboestrol is contraindicated in conditions like Hypertension,Vaginal bleeding,Sickle cell anaemia,Porphyrias,Thromboembolism,Premenopausal breast cancer.
Effects
The severe or irreversible adverse effects of Stilboestrol, which give rise to further complications include Impotence, Testicular atrophy, Thromboembolic disorder, Thrombosis.Stilboestrol produces potentially life-threatening effects which include Hepatotoxicity, Thromboembolic disease. which are responsible for the discontinuation of Stilboestrol therapy.The signs and symptoms that are produced after the acute overdosage of Stilboestrol include Nausea & vomiting.The symptomatic adverse reactions produced by Stilboestrol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nipple tenderness, Nausea and vomiting, Breast discomfort, Breast enlargement.
Indications
Stilboestrol is primarily indicated in conditions like Adjunct in the treatment of opiod dependence, Oncology, Prostatic cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Breast cancer, Prostate cancer.
Interactions
Stilboestrol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementPhenobarbitonePromazine (HCl)RifampicinTheophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Test for Oestrogen measurement in Urine
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 25°C. Protect from Sunlight.
Warnings
High doses of estrogen used in treatment of malignant disease should be used cautiously in patients with cerebrovascular disorder, cardiovascular disease, coronary artery disease, venous thromboembolism or liver impairment. Estrogens should be used with caution in children, because premature closure of epiphysis may occur resulting in inhibited linear growth and small stature. Slow infusion is not recommended, because cytotoxic concentration of drug is not achieved. It is not recommended for use during pregnancy.
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