Spiramycin

Spiramycin is antibiotic and is used to treat a large variety of bacterial infections, such as respiratory tract infections, middle ear infections, skin infections and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Spiramycin is important to take the drug for the full time period as prescribed, discontinuation of the drug may result in ineffective treatment.

Brands
ROVAMYCINE ROVAMYCIN FORTE USAMYCIN USAMYCIN
Adult Dose
Dose: 1000 mg
Single Dose: 1000 (1000)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Dose: 16.66 to 33.33 m/kg
Single Dose: 25 (24.995)
Frequency: 8 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 16.66 to 33.33 mg/kg
Single Dose: 25 (24.995)
Frequency: 8 hourly
Route: Oral
Instructions:
Characteristics
. It is of Semi Synthetic origin and belongs to Macrolide Antibiotic. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Macrolide pharmacological group.The Molecular Weight of Spiramycin is 843.00. Its pKa is 8.0.
Contraindications
Spiramycin is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Spiramycin, which give rise to further complications include Urticaria, Angioedema, Paresthesia, Colitis.Spiramycin produces potentially life-threatening effects which include Neuromuscular blockage, Ventricular arrhythmias. which are responsible for the discontinuation of Spiramycin therapy.The signs and symptoms that are produced after the acute overdosage of Spiramycin include Headache, Abdominal pain, Nausea & vomiting, Arrhythmias.The symptomatic adverse reactions produced by Spiramycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Anaphylactic shock.
Indications
Spiramycin is primarily indicated in conditions like Depression, Menopausal symptoms, Nerve weakness, and can also be given in adjunctive therapy as an alternative drug of choice in Fibromyalgia.
Interactions
Spiramycin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAstemizoleCarbidopaCimetidine (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of spiramycin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects . These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased transaminases levels
Risks
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, Between 20°C-25°C. Protect from Sunlight, Moisture and Heat.
Warnings
Antibiotic-associated colitis has been reported with use of spiramycin. Observe for superinfections. Rare hepatic impairment with or without jaundice has occurred with macrolides, it may be accompanied by malaise, nausea, vomiting, abdominal colic, and fever, discontinue use if these occur.
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