Spectinomycin (HCl)

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. Spectinomycin (HCl) is structurally related to aminoglycosides. Spectinomycin lacks amino sugar and glycosidic bonds. Spectinomycin has moderate antibacterial activity against many gram positive and gram negative bacteria but Spectinomycin (HCl) is especially effective against Niesseria gonorrhoeae. Antibiotics require constant drug level in body for therapeutic effect. This is achieveD by taking the medication at regular intervals of time throughout the day and night as prescribed. Spectinomycin (HCl) is important to take the drug for the full time period as prescribed, discontinuation of the therapy may result in ineffective treatment.

Brands
TROBICIN U-VEIL
Adult Dose
Dose: 2000 to 4000 mg
Single Dose: 3000 (3000)
Frequency: 24 hourly
Route: IM
Instructions: Single Dose
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Semi Synthetic origin and belongs to Aminocyclitol Antibiotic. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Spectinomycin (HCl) is 495.40. It is weakly acidic drug, 5.66% solution of the drug is isotonic and Its pKa is 6.88, 8.84.
Contraindications
Spectinomycin (HCl) is contraindicated in conditions like Pharyngeal gonorrhoea,Complicated gonococcal infection.
Effects
Spectinomycin (HCl) produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Spectinomycin (HCl) therapy.The symptomatic adverse reactions produced by Spectinomycin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Fever, Chills, Urticaria.
Indications
Spectinomycin (HCl) is primarily indicated in conditions like Cervicitits, Gonorrhoea, Proctitis, Urethritis.
Interactions
Spectinomycin (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementBotulinum B ToxinBotulinum Toxin Type ALithium These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Reduced Haematocrit, Haemoglobin, Creatinine Clearance Increased Alkaline Phosphatase
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Dry Powder for Inj Store in a well closed container, at room temperature, Below 30°C. Protect from Moisture. Inj (reconsitututed soln) Store at room temperature. Use within 24 hrs if kept at room temperature.
Warnings
Patients receiving spectinomycin for gonorrhea should be tested for syphilis at the time of treatment and 3 months later because the symptoms of syphilis may be masked or delayed by treatment with spectinomycin. Spectinomycin should be used with caution during pregnancy and in the breast feeding mother. Spectinomycin should be used with caution in children because safe use has not been fully established. Spectinomycin reconstituted with bacteriostatic water containing benzyl alcohol should not be administered to neonates. CNS toxicity in neonates and infants has been blamed on inadvertent administration of benzyl alcohol.
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