EPIVAL EPIVAL EPIVAL EPIVAL EPIVAL EPIVAL VALPRO VALPRO VALPRO EPILIM CHRONO EPIRATE EPIRATE DAPAKAN DAPAKAN DAPAKAN EPIVAL-CR EPIVAL-CR VALEP VALEP VALEP VALEP ORIFRAL EPILIM EPILIM MALPRATE-D MALPRATE-D SOPRAT DIVAREX DIVAREX EPIMED EPIMED LEPTIL LEPTIL LEPTIL VAZIPRO VAZIPRO VAZIPRO VAZIPRO CARALIUM CARALIUM PRIZM PRIZM PRIZM PRIZM PSY-CARE WIPROATE WIPROATE VALTEC VALTEC DIPODIUM DIPODIUM DIPODIUM DIPODIUM REVALP REVALP REVALP REVALP SONAVATE VOLPAR VOLPAR

Dose: 1 to 2 g
Single Dose: 1.5 (1.5)
Frequency: 12 hourly
Route: PO
Instructions: As maintenance dose.

Dose: 6 to 12 mg/kg
Single Dose: 9 (9)
Frequency: 8 hourly
Route: Intravenous
Instructions:

Dose: 20 to 30 mg/kg
Single Dose: 25 (25)
Frequency: 24 hourly
Route: Oral
Instructions: Maintenance doses , exceed upto 35mg/kg

Sodium Valproate also known as Divalprex Sodium. . It is of Synthetic origin and belongs to Valproic Acid. It belongs to Na-Channel Antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Sodium Valproate is 166.20. Its pKa is 4.95.

Sodium Valproate

The severe or irreversible adverse effects of Sodium Valproate, which give rise to further complications include Thrombocytopenia.Sodium Valproate produces potentially life-threatening effects which include Pancreatitis, Liver damage, Extrapyrimidal symptoms, Hyperammonemia. which are responsible for the discontinuation of Sodium Valproate therapy.The signs and symptoms that are produced after the acute overdosage of Sodium Valproate include Death, Deepening coma.The symptomatic adverse reactions produced by Sodium Valproate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weight gain, Tremor, Hair loss, GI disorders, Hematological disorder, Leucopenia, bone marrow depression, nocturnal enuresis, curly hair development.

Sodium Valproate is primarily indicated in conditions like All forms of epilepsy, Generalised epilepsy with absence seizures, Prophylaxis of febrile convulsion, Prophylaxis of post traumatic epilepsy, Status epilepticus, and can also be given in adjunctive therapy as an alternative drug of choice in Alcohol withdrawal, Mania, Nelsons syndrome, Tardive dyskinesias.

Sodium Valproate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinCarbamazepineErythromycinEthosuximideEthosuximideFosphenytoinLamotrigineMefloquine (HCl)MeropenemMethotrexatePhenobarbitonePhenytoin (Na)PrimidoneWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

False +ve test for ketones by Urine Analysis

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Syrup Store Below 40°C. Protect from Sunlight and Heat.

Sodium valporate should be used with caution in patients with liver disease, bleeding disorder, history of a brain disorder or any allergy. It should be used caution while driving motor vehicles or performing tasks that require alertness. Before having surgery, including dental surgery, inform the doctor about the use of drug. This may interfere with urine ketone testing and give false positive results, if very high sugar readings (e.g.over 300) are occurring, ketones may be present in urine, contact the doctor or pharmacist. It should be used with extreme caution in children under 2 years old as serious liver problems exist.The drug is not recommended for use during pregnancy or lactation, Because it may cause some neural tube defect. Avoid use in pancreatitis,porphyria. Use with caution in HIV, lupus erythrematosus risk of weight gain associated with it.