Sodium Thiosulphate

Sodium Thiosulphate used in the treatment of cyanide or arsenic poisoning in conjunction with sodium nitrite.


Brands
Adult Dose
Dose: 17.86 mg/kg.min
Single Dose: 18 (17.86)
Frequency: 24 hourly
Route: IV Inf
Instructions: For 10 Minutes
Neonatal
Dose: 250 mg/kg
Single Dose: 250 (250)
Frequency: As recommended.
Route: Slow IV
Instructions: Given over 10 Minutes
Paedriatic
Dose: 250 mg/kg
Single Dose: 250 (250)
Frequency: As recommended.
Route: Slow IV
Instructions: Given over 10 Minutes
Characteristics
. It is of Synthetic origin. It belongs to Antidotes pharmacological group.The Molecular Weight of Sodium Thiosulphate is 158.10. It is weakly alkaline drug, 2.98% solution of the drug is isotonic and Its pKa is 1.6.
Contraindications
Sodium Thiosulphate is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Sodium Thiosulphate, which give rise to further complications include Irritation, Itching, Hives.Sodium Thiosulphate produces potentially life-threatening effects which include Hypotension. which are responsible for the discontinuation of Sodium Thiosulphate therapy.The symptomatic adverse reactions produced by Sodium Thiosulphate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Burning, Stinging on application.
Indications
Sodium Thiosulphate is primarily indicated in conditions like Cyanide poisoning, Poisoning with cyanogenic substances, Skin diseases.
Interactions
No data regarding the interactions of Sodium Thiosulphate was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj, lotions Store in a well closed container, . Protect from Moisture and Heat.
Warnings
Discontinue topical use if irritation or sensitivity occurs. Can increase risk of thiocyanate intoxication. Safety in pregnancy has not been established. Discontinue topical use if irritation or sensitivity occurs
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