Dose: 4.64 to 8.57 mg/kg
Single Dose: 6.6 (6.605)
Frequency: 4 hourly
Route: PO
Instructions: -

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

. It is of Synthetic origin and belongs to Hydoroxybenzoate. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Sodium Salicylate is 160.10. It is weakly acidic drug, 2.53% solution of the drug is isotonic and Its pKa is 2.9, 13.4.

Sodium Salicylate is contraindicated in conditions like Peptic ulcer,Renal diseases,Gastritis.

'The severe or irreversible adverse effects of Sodium Salicylate, which give rise to further complications include Hepatotoxicity, Gastric irritation, Mucosal lesions, Worsening of pre-existing heart failure.Sodium Salicylate produces potentially life-threatening effects which include Hypersensitivity reactions, Reye''s syndrome. which are responsible for the discontinuation of Sodium Salicylate therapy.The signs and symptoms that are produced after the acute overdosage of Sodium Salicylate include Acidosis, Fever, Hyperglycemia, Hypoglycemia, Renal failure, Respiratory alkalosis.The symptomatic adverse reactions produced by Sodium Salicylate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Tachycardia, Rashes, Hyperventilation, Metabolic acidosis, Respiratory alkalosis, Salicylism.'

Sodium Salicylate is primarily indicated in conditions like Fever, Pain, Rheumatoid arthritis.

Sodium Salicylate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholFludrocortisone (Acetate)MethotrexateSalicylates interfere with the excretion of methotrexate and may displace it from binding site result in increased toxicity.MajorMonitor patient for signs and symptoms of bone marrow suppression and nephrotoxicity.ProbenecidSpironolactoneTeniposideConcurrent use may result in potentiation of drug toxicity.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Test for Urinary Glucose, Oestrogens, 17-OH-Corticosteroids, Ketones Serum Uric Acid Test

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Sodium salicylate should be used with caution in patients with chronic renal (kidney) insufficiency, gastric ulcer, severe anaemia, patients intolerant to salicylate.