Sodium Nitrite

Sodium Nitrite used in conjuction with sodium thiosulphate in the treatment of cyanide poisoning. It forms cyanomethhaemoglobin which does not demage the cell respiration and eventually converted into less toxic thiocyanate by the thiosulphate.

Brands
Adult Dose
Dose: 4.29 mg/kg
Single Dose: 4.3 (4.29)
Frequency: As recommended.
Route: IV
Instructions: Every 1/2 hour till required
Neonatal
Dose: 3.33 mg/kg.min
Single Dose: 3.3 (3.33)
Frequency: As recommended.
Route: IV Infusion
Instructions: For 3 Min or As Required
Paedriatic
Dose: 3.33 mg/kg.min
Single Dose: 3.3 (3.33)
Frequency: As recommended.
Route: IV Infusion
Instructions: For 3 Min or As Required
Characteristics
. It is of Synthetic origin and belongs to Sodium Salt. It belongs to Antidotes pharmacological group.The Molecular Weight of Sodium Nitrite is 69.00. It is weakly alkaline drug, 1.08% solution of the drug is isotonic.
Contraindications
Sodium Nitrite is contraindicated in conditions like Methaemoglobinaemia,Haemolytic anaemia,G6pd deficiency.
Effects
Sodium Nitrite produces potentially life-threatening effects which include Hypotension, Methemoglobinemia. which are responsible for the discontinuation of Sodium Nitrite therapy.The signs and symptoms that are produced after the acute overdosage of Sodium Nitrite include Poisoning.
Indications
Sodium Nitrite is primarily indicated in conditions like Cyanide poisoning, Poisoning.
Interactions
No data regarding the interactions of Sodium Nitrite was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in a well closed container.
Warnings
It should not be given in patients with hypotension. Solution is unstable and should be used just before use.
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