Sodium Calciumedetate

Sodium Calciumedetate is a chelating agent. Sodium Calciumedetate is used in the treatment of lead poisoning.


Brands
Adult Dose
Dose: 14.29 mg/kg.hr
Single Dose: 14 (14.29)
Frequency: 12 hourly
Route: IV Inf
Instructions: Upto 2.1-2.8 Hours for 5 Days
Neonatal
Dose: 40 mg/kg
Single Dose: 40 (40)
Frequency: 12 hourly
Route: IV Infusion
Instructions: Treat up to 5 days
Paedriatic
Dose: 40 mg/kg
Single Dose: 40 (40)
Frequency: 12 hourly
Route: IV Infusion
Instructions: Treat for up to 5 days
Characteristics
Sodium Calciumedetate also known as Calcium-EDTA, Calcium-EDTA, Calcium-EDTA. . It is of Synthetic origin and belongs to Chelating Agent. It belongs to Chelating Agent pharmacological group.The Molecular Weight of Sodium Calciumedetate is 410.30. It is weakly acidic drug, 4.50% solution of the drug is isotonic.
Contraindications
Sodium Calciumedetate is contraindicated in conditions like Renal insufficiency.
Effects
The severe or irreversible adverse effects of Sodium Calciumedetate, which give rise to further complications include Renal tubular changes.The symptomatic adverse reactions produced by Sodium Calciumedetate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Headache, Fatigue, Malaise, Nausea and vomiting, Urinary urgency, Urinary frequency.
Indications
Sodium Calciumedetate is primarily indicated in conditions like Lead poisoning, Skin diseases.
Interactions
Sodium Calciumedetate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmphotericin BInsulinConcurrent use will decrease the duration of action of zinc insulin preparations by chelation of zinc.Zinc ChlorideConcurrent use may decrease the effectiveness of edetate calcium disodium and zinc supplements due to chelation.Zinc supplement therapy should be withheld until edetate calcium disodium therapy is completed.Zinc CitrateConcurrent use may decrease the effectiveness of edetate calcium disodium and zinc supplements due to chelation.Zinc supplement therapy should be withheld until edetate calcium disodium therapy is completed.Zinc OxideConcurrent use may decrease the effectiveness of edetate calcium disodium and zinc supplements due to chelation.Zinc supplement therapy should be withheld until edetate calcium disodium therapy is completed.Zinc PhenolsulphonateConcurrent use may decrease the effectiveness of edetate calcium disodium and zinc supplements due to chelation.Zinc supplement therapy should be withheld until edetate calcium disodium therapy is completed.Zinc PyrithioneConcurrent use may decrease the effectiveness of edetate calcium disodium and zinc supplements due to chelation.Zinc supplement therapy should be withheld until edetate calcium disodium therapy is completed.Zinc SulphateConcurrent use may decrease the effectiveness of edetate calcium disodium and zinc supplements due to chelation.Zinc supplement therapy should be withheld until edetate calcium disodium therapy is completed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Urinanalysis Serum test for Creatinine and Glucose Monitoring of Serum phosphate levels
Risks
Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C.
Warnings
Sodium calciumedetate should be used with caution in patients with impaired renal function. Regular monitoring of renal function for proteinuria and haematuria has been recommended. It should not be given by mouth in the treatment of lead poisoning.
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