Aurothiomalate

Aurothiomalate is a parentrally administered preparation of Gold. Gold compounds were introduced for the treatment of rheumatoid arthritis in the 1920s. Aurothiomalate is administered intramuscularly as water soluble gold salt containing 50 % elemental gold. Gold therapy is indicated for active rheumatoid arthritis.

Brands
Adult Dose
Dose: 0.714 mg/kg
Single Dose: 0.71 (0.714)
Frequency: As recommended.
Route: IM
Instructions: Once in a Week, For 5 Months
Neonatal
Paedriatic
Dose: 0.25 to 0.5 mg/kg
Single Dose: 0.38 (0.375)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Initial, gradually increased
Characteristics
. It is of Synthetic origin and belongs to Gold Compound. It belongs to Immune Modifiers pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Aurothiomalate is 2500.00. Its pKa is 3.2.
Contraindications
Aurothiomalate is contraindicated in conditions like Bone marrow depression,Nephritis.
Effects
The severe or irreversible adverse effects of Aurothiomalate, which give rise to further complications include Renal damage, Thrombocytopenia, Musculoskeletal effects.Aurothiomalate produces potentially life-threatening effects which include Bone marrow aplasia, Neutropenia, Pancytopenia. which are responsible for the discontinuation of Aurothiomalate therapy.The signs and symptoms that are produced after the acute overdosage of Aurothiomalate include Nausea, Vomiting, Erythematous rash, Exfoliative dermatitis, Stomatitis, Pharyngitis, Tracheitis, Gastritis, Colitis, Vaginitis, BLood dyscrasias, Albuminuria, Hematuria, Acute renal failure, Encephalitis, Polyneuropathy, Jaundice.The symptomatic adverse reactions produced by Aurothiomalate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Mouth ulcers, Skin RashX.
Indications
Aurothiomalate is primarily indicated in conditions like Juvenile chronic arthritis, Palindromic rheumatism, Psoriatic arthritis, Rheumatoid arthritis.
Interactions
No data regarding the interactions of Aurothiomalate was found.
Interfrence
Risks
Drug should not be given to Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Protect from Sunlight.
Warnings
Do not use Penicillamine or antimalarial with gold salts such as aurothiomalate. Before initiating treatment rule out pregnancy, perform complete blood count, urine analysis, liver and renal function test. Use with caution in patients with compromised cardiovascular or cerebral circulation.
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